Krutetskaia Z I, Lebedev O E, Krutetskaia N I
St. Petersburg State University, Russia.
Ross Fiziol Zh Im I M Sechenova. 2000 Aug;86(8):1030-48.
Mechanisms of the Ca2+ signal generation and regulation in peritoneal macrophages activated with purinergic agonists (ATP, UTP), as well as endoplasmic Ca(2+)-ATPase inhibitors, were investigated. Using a wide range of drugs affecting the intracellular signaling systems' components, an important role of second messenger systems and other key functional cellular systems in Ca2+ signals regulation in the macrophages, was shown.
研究了嘌呤能激动剂（ATP、UTP）以及内质网Ca(2+)-ATP酶抑制剂激活的腹膜巨噬细胞中Ca2+信号产生和调节的机制。通过使用多种影响细胞内信号系统组分的药物，揭示了第二信使系统和其他关键功能性细胞系统在巨噬细胞Ca2+信号调节中的重要作用。
