Marcucci R, Bertini L, Liotta A A, Rogolino A, Antonucci E, Ilari I, Pepe G, Prisco D
Dipartimento Area Critica Medico-Chirurgica, Università degli Studi di Firenze.
Ann Ital Med Int. 2000 Jul-Sep;15(3):195-8.
Central retinal vein occlusion is one of the most common retinal vascular disorders. Few and contrasting data are available on the prevalence of hemostatic risk factors in patients with central retinal vein occlusion. The aim of this study was to investigate the most common hemostasis-related inherited risk factors for venous thrombosis in a group of 53 central retinal vein occlusion patients (median age 59 years, range 18-77 years) and in 53 comparable control subjects (median age 57 years, range 22-84 years). No difference was found in antithrombin III, protein C and protein S plasma levels between patients and controls. At univariate analysis, activated protein C resistance (odds ratio 5.8) and factor V Leiden (odds ratio 4.4) were significantly associated with central retinal vein occlusion whereas G20210A polymorphism of the prothrombin gene was not. After adjustment for sex, age, and the other classic vascular risk factors (hypertension, diabetes, hypercholesterolemia, smoking) activated protein C resistance remained the only independent risk factor for central retinal vein occlusion (odds ratio 11.5). These data indicate that activated protein C resistance may play a role in the pathophysiology of central retinal vein occlusion.
视网膜中央静脉阻塞是最常见的视网膜血管疾病之一。关于视网膜中央静脉阻塞患者止血危险因素的患病率，现有数据较少且相互矛盾。本研究的目的是调查一组53例视网膜中央静脉阻塞患者（中位年龄59岁，范围18 - 77岁）和53例匹配的对照受试者（中位年龄57岁，范围22 - 84岁）中最常见的与止血相关的遗传性静脉血栓形成危险因素。患者和对照组之间的抗凝血酶III、蛋白C和蛋白S血浆水平未发现差异。单因素分析显示，活化蛋白C抵抗（比值比5.8）和因子V莱顿突变（比值比4.4）与视网膜中央静脉阻塞显著相关，而凝血酶原基因的G20210A多态性则不然。在对性别、年龄和其他经典血管危险因素（高血压、糖尿病、高胆固醇血症、吸烟）进行校正后，活化蛋白C抵抗仍然是视网膜中央静脉阻塞的唯一独立危险因素（比值比11.5）。这些数据表明，活化蛋白C抵抗可能在视网膜中央静脉阻塞的病理生理过程中起作用。
