Weisner B, Bernhardt W
Eur Neurol. 1979;18(2):111-5. doi: 10.1159/000115064.
114 patients suffering from generalized grand mal seizures were treated with phenytoin only. Serum-phenytoin was monitored, and its relation to the frequency of attacks was established in each case, observing steady state periods of at least 3 months' duration. In a group of 44 patients the reduction in pretreatment frequency of attacks was used to evaluate the drug effect. The probability of attacks followed an exponential function of serum-phenytoin. Curves of equal probability for further attacks were plotted: they may assist in determining the initial regimen. However, the high variability in responsiveness during a serum-phenytoin below 10 mg/l suggested that the effective level has to be determined separately and repeatedly for every single patient.
114名患有全身性癫痫大发作的患者仅接受苯妥英治疗。监测血清苯妥英水平，并在每种情况下确定其与发作频率的关系，观察至少持续3个月的稳态期。在一组44名患者中，使用治疗前发作频率的降低来评估药物效果。发作概率遵循血清苯妥英的指数函数。绘制了进一步发作的等概率曲线：它们可能有助于确定初始治疗方案。然而，血清苯妥英水平低于10mg/l时反应性的高变异性表明，必须为每个患者单独且反复地确定有效水平。
