Hillen H F
Department of Internal Medicine, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Postgrad Med J. 2000 Nov;76(901):690-3. doi: 10.1136/pmj.76.901.690.
Unknown primary tumours (UPTs) are defined by the absence of a primary tumour in biopsy proved metastatic cancer. These tumours have a specific biology with clinical characteristics of rapid progression and random atypical metastases. Cytogenetic abnormalities have been demonstrated, particularly deletion of chromosome 1p. Diagnostic evaluation that includes pathology review, physical examination, chest radiography, computed tomography of the abdomen, and mammography is directed at the identification of treatable subsets. Based on clinicopathological criteria, therapy responsive subsets of patients with UPTs can be defined. These subsets have a better prognosis than the average median survival time of four months in patients with UPTs.
未知原发肿瘤（UPTs）的定义是，经活检证实为转移性癌症但未发现原发肿瘤。这些肿瘤具有特定的生物学特性，临床特征为进展迅速且转移随机且不典型。已证实存在细胞遗传学异常，尤其是1p染色体缺失。包括病理复查、体格检查、胸部X线摄影、腹部计算机断层扫描和乳房X线摄影在内的诊断评估旨在识别可治疗的亚组。根据临床病理标准，可以定义对治疗有反应的UPTs患者亚组。这些亚组的预后优于UPTs患者平均四个月的中位生存时间。
