MKP - 5基因DUSP10/Dusp10的表达及比较染色体定位
Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10.
作者信息
Masuda K, Shima H, Kikuchi K, Watanabe Y, Matsuda Y
机构信息
Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
出版信息
Cytogenet Cell Genet. 2000;90(1-2):71-4. doi: 10.1159/000015666.
We have isolated a mouse cDNA for a novel MAPK phosphatase, designated as MKP-5. Two MKP-5 mRNA transcripts of 3.5 kb and 2.7 kb were detected. The 3.5-kb transcript was expressed in almost all the tissues examined, and was particularly abundant in cerebellum, skeletal muscle, and bone marrow. On the other hand, the 2.7-kb transcript was specifically and highly expressed in testis. The MKP-5 genes (DUSP10/Dusp10) were localized to chr 1q41, Chr 1H5 and chr 13q26 in human, mouse and rat, respectively. They were mapped in regions where conserved linkage homology has been identified among the three species.
我们分离出了一种新型丝裂原活化蛋白激酶磷酸酶（MAPK磷酸酶）的小鼠cDNA，命名为MKP-5。检测到了3.5 kb和2.7 kb的两种MKP-5 mRNA转录本。3.5 kb的转录本在几乎所有检测的组织中都有表达，在小脑、骨骼肌和骨髓中尤其丰富。另一方面，2.7 kb的转录本在睾丸中特异性高表达。MKP-5基因（DUSP10/Dusp10）在人、小鼠和大鼠中分别定位于1号染色体q41、1号染色体H5和13号染色体q26。它们被定位在三个物种中已确定存在保守连锁同源性的区域。
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