中国仓鼠与小鼠、大鼠和人类的比较细胞遗传图谱构建。
Construction of comparative cytogenetic maps of the Chinese hamster to mouse, rat and human.
作者信息
Kuroiwa A, Tsuchiya K, Matsubara K, Namikawa T, Matsuda Y
机构信息
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
出版信息
Chromosome Res. 2001;9(8):641-8. doi: 10.1023/a:1012952223509.
We constructed comparative cytogenetic maps of the Chinese hamster to mouse, rat and human by fluorescence in-situ hybridization using 36 cDNA clones of mouse, rat, Syrian hamster, Chinese hamster and human functional genes. In this study, 30 out of the 36 genes were newly mapped to Chinese hamster chromosomes. The chromosomal homology of the Chinese hamster was identified and arranged in 19, 19 and 18 segments of conserved synteny in mouse, rat and human, respectively. Additionally, two of the 19 segments homologous to mouse chromosomes were initially identified in this study.
我们通过荧光原位杂交技术，利用小鼠、大鼠、叙利亚仓鼠、中国仓鼠和人类功能基因的36个cDNA克隆构建了中国仓鼠与小鼠、大鼠和人类的比较细胞遗传图谱。在本研究中，36个基因中的30个被新定位到中国仓鼠染色体上。中国仓鼠的染色体同源性分别在小鼠、大鼠和人类中被鉴定并排列成19、19和18个保守同线区段。此外，本研究首次鉴定出与小鼠染色体同源的19个区段中的两个。
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