Bellm L, Lehrer R I, Ganz T
CHS 37-055, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA.
Expert Opin Investig Drugs. 2000 Aug;9(8):1731-42. doi: 10.1517/13543784.9.8.1731.
Protegrins and their derivatives are a new class of peptide antibiotics based on mammalian antimicrobial peptides. Their pharmacological properties include an unusually broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi and some enveloped viruses. Preclinical and clinical studies of the lead compound, IB-367, developed for topical applications, show promise for the prevention of chemotherapy- and radiation-induced oral mucositis.
防御素及其衍生物是一类基于哺乳动物抗菌肽的新型肽类抗生素。它们的药理特性包括对革兰氏阳性菌和革兰氏阴性菌、真菌及一些包膜病毒具有异常广泛的抗菌活性。针对局部应用开发的先导化合物IB - 367的临床前和临床研究显示，其在预防化疗和放疗引起的口腔黏膜炎方面具有前景。
