Chen Y F, Oparil S
Department of Medicine, University of Alabama at Birmingham 35294-0007, USA.
Am J Med Sci. 2000 Oct;320(4):223-32. doi: 10.1097/00000441-200010000-00001.
The pulmonary endothelium modulates vascular tone by the release of endothelium-derived constricting (EDCF) and relaxing (EDRF) factors, among them endothelin-1, nitric oxide, prostacyclin, and putative endothelium-derived hyperpolarizing factors. Abnormalities in EDCF and EDRF generation have been demonstrated in a number of cardiopulmonary disease states, such as primary and secondary pulmonary hypertension, chronic obstructive lung disease, cardiopulmonary bypass, and congestive heart failure. An imbalance between EDCF and EDRF, termed "pulmonary endothelial dysfunction," may contribute to the alteration in vascular tone characteristic of pulmonary disease. The following review summarizes the present knowledge of the role of EDCF and EDRF in such processes with major focus on pulmonary endothelial dysfunction in hypoxia-induced pulmonary hypertension.
肺内皮细胞通过释放内皮源性收缩因子（EDCF）和舒张因子（EDRF）来调节血管张力，其中包括内皮素-1、一氧化氮、前列环素以及假定的内皮源性超极化因子。在许多心肺疾病状态下，如原发性和继发性肺动脉高压、慢性阻塞性肺疾病、体外循环和充血性心力衰竭，均已证实存在EDCF和EDRF生成异常。EDCF和EDRF之间的失衡，即“肺内皮功能障碍”，可能导致肺部疾病特有的血管张力改变。以下综述总结了目前关于EDCF和EDRF在这些过程中的作用的知识，主要关注缺氧诱导的肺动脉高压中的肺内皮功能障碍。
