功能性体液移植免疫的系统发育：两栖动物和啮齿动物的比较研究

Phylogeny of functional humoral transplantation immunity: comparative studies in amphibians and rodents.

作者信息

Cohen N, Baldwin W M, Manickavel V

出版信息

Adv Exp Med Biol. 1975;64:411-20. doi: 10.1007/978-1-4684-3261-9_41.

Abstract

Remarkably comparable observations from parallel experiments in salamanders and mice utilizing three related model systems (implant-induced immunomanipulation; passive transfer; and putative B cell suppression) argue directly that functional humoral transplantation immunity is highly developed at the phylogenetic level of Amphibia and that it plays a major role in regulating graft survival in these species (Fig. 4). Although it is still conjectural whether such humoral immunity and weak H-antigens evolved concurrently, the argument that enhancing atibodies evolved exclusively in viviparous species to protect the fetus from potential rejection by the maternal immune system no longer seems tenable (1).

摘要

在蝾螈和小鼠中利用三种相关模型系统（植入诱导的免疫操纵；被动转移；以及假定的B细胞抑制）进行的平行实验得出了非常相似的观察结果，这直接表明功能性体液移植免疫在两栖动物的系统发育水平上高度发达，并且在调节这些物种的移植物存活中起主要作用（图4）。尽管这种体液免疫和弱H抗原是否同时进化仍属推测，但认为增强抗体仅在胎生物种中进化以保护胎儿免受母体免疫系统潜在排斥的观点似乎不再站得住脚（1）。