Vázquez Forner C, Giménez Climent J, Fliquete Peris M V, Fuster Diana C, Más Arcas C, Vázquez Albaladejo C
Servicio de Medicina Nuclear, Fundación Instituto Valenciano de Oncología, Valencia.
Rev Esp Med Nucl. 2000 Jun;19(3):207-10.
The sentinel node biopsy appears to offer an alternative to routine axillary lymph node dissection for staging patients with breast cancer. Various techniques have been studied for identifying the sentinel node, using vital blue or radioactive colloid. This study aimed to evaluate our preliminary results with these techniques.
In this work carried out in the Valencian Institute of Oncology, 21 women with T1- T2 breast cancer with an average age of 52 years (range: 42-73) underwent the sentinel node biopsy, which was immediately followed by standard axillary dissection. Both blue dye and radioisotope were used to identify the sentinel node. The radioactive axillary of sentinel node was localized by the gamma probe.
The sentinel node was successfully identified by lymph node scintigraphy in 100%. It was localized by blue dye in 33% and by combination of blue dye and isotope in 95%. Of the 21 patients in this study in whom sentinel nodes were identified, 7 (35%) were histologically positive; in 6 cases, the sentinel was the only site of the metastases (86%). The histology of the sentinel node accurately predicted axillary node status in 95% of cases.
The sentinel node biopsy technique is a promising and feasible procedure in patients with clinically T1-T2 N0M0 breast cancer, providing valuable axillary staging information.
前哨淋巴结活检似乎为乳腺癌患者分期提供了一种替代常规腋窝淋巴结清扫的方法。已经研究了多种使用活性蓝色染料或放射性胶体来识别前哨淋巴结的技术。本研究旨在评估我们使用这些技术的初步结果。
在巴伦西亚肿瘤研究所开展的这项研究中，21例患有T1 - T2期乳腺癌的女性患者（平均年龄52岁，范围：42 - 73岁）接受了前哨淋巴结活检，随后立即进行标准腋窝清扫。同时使用蓝色染料和放射性同位素来识别前哨淋巴结。前哨淋巴结的放射性腋窝定位通过γ探测仪进行。
通过淋巴结闪烁扫描术成功识别前哨淋巴结的比例为100%。通过蓝色染料定位的比例为33%，通过蓝色染料与同位素联合定位的比例为95%。在本研究中识别出前哨淋巴结的21例患者中，7例（35%）组织学检查呈阳性；在6例中，前哨淋巴结是转移的唯一部位（86%）。前哨淋巴结的组织学检查在95%的病例中准确预测了腋窝淋巴结状态。
前哨淋巴结活检技术对于临床T1 - T2 N0M0期乳腺癌患者是一种有前景且可行的方法，可提供有价值的腋窝分期信息。
