解码参与心脏生长和功能的钙信号。

Decoding calcium signals involved in cardiac growth and function.

作者信息

Frey N, McKinsey T A, Olson E N

机构信息

Department of Molecular Biology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.

出版信息

Nat Med. 2000 Nov;6(11):1221-7. doi: 10.1038/81321.

DOI:10.1038/81321

PMID:11062532

Abstract

Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.

摘要

钙在心脏收缩性、生长及基因表达的调节中起核心作用。钙信号在幅度、频率和区域化方面的变化由钙/钙调蛋白依赖性酶、离子通道及转录因子进行解码。了解钙信号传导通路为心脏功能的药理学修饰创造了机会。