解码参与心脏生长和功能的钙信号。
Decoding calcium signals involved in cardiac growth and function.
作者信息
Frey N, McKinsey T A, Olson E N
机构信息
Department of Molecular Biology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.
出版信息
Nat Med. 2000 Nov;6(11):1221-7. doi: 10.1038/81321.
DOI:10.1038/81321
PMID:11062532
Abstract
Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.
摘要
钙在心脏收缩性、生长及基因表达的调节中起核心作用。钙信号在幅度、频率和区域化方面的变化由钙/钙调蛋白依赖性酶、离子通道及转录因子进行解码。了解钙信号传导通路为心脏功能的药理学修饰创造了机会。
Zotero 插件