Paloczi K
Department of Immunology, Faculty of Health Sciences, Semmelweis University, National Institute of Haematology and Immunology, P.O. Box 424, H-1519, Budapest, Hungary.
Immunol Lett. 2000 Nov 1;74(3):177-81. doi: 10.1016/s0165-2478(00)00270-4.
The recipients of allogeneic haematopoietic stem cell transplants are characterised by an immunodeficiency of varying severity and duration. Their immunocompromised state is due in part to: (1) an impaired recapitulation of lymphoid ontogeny, (2) a lack of sustained transfer of donor immunity, (3) the effects of graft versus host disease and its therapy, and (4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens. T-cell proliferation as well as immunoglobulin production remains impaired usually until the second half of the first year post-transplant. Other factors that can influence immunological reconstitution include the donor-recipient relationship (histocompatible or matched unrelated donor), intervening infections and recipient age, among others.
异基因造血干细胞移植受者的特点是存在不同严重程度和持续时间的免疫缺陷。他们的免疫功能低下状态部分归因于：（1）淋巴细胞发育的重现受损，（2）缺乏供体免疫的持续传递，（3）移植物抗宿主病及其治疗的影响，以及（4）胸腺功能降低。移植后受者幼稚T淋巴细胞的产生可能会延迟，这导致新的抗原特异性T淋巴细胞产生缺陷以及无法产生抗体，尤其是针对碳水化合物抗原的抗体。T细胞增殖以及免疫球蛋白的产生通常在移植后第一年下半年之前仍然受损。其他可能影响免疫重建的因素包括供体 - 受体关系（组织相容性或匹配的无关供体）、介入感染和受者年龄等。
