针对荚膜多糖的免疫保护性抗体不影响肺炎链球菌的自然感受态：对当前结合疫苗接种策略有何影响？

Immune-protective antibodies against capsular polysaccharides do not affect natural competence of Streptococcus pneumoniae: implications for current conjugate vaccination strategies?

作者信息

Overweg K, Sluijter M, Srodzinski M, de Groot R, Hermans P W

机构信息

Department of Pediatrics, Sophia Children's Hospital, Laboratory of Pediatrics/room Ee 1500, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands.

出版信息

FEMS Immunol Med Microbiol. 2000 Nov;29(3):183-5. doi: 10.1111/j.1574-695X.2000.tb01521.x.

DOI:10.1111/j.1574-695X.2000.tb01521.x

Abstract

We studied the effect of opsonization of Streptococcus pneumoniae with capsular antibodies on horizontal transfer of DNA. Opsonization did not inhibit DNA uptake. This suggests that horizontal transfer of capsular genes, which is an important escape mechanism of the pathogen, remains a potential threat for the efficacy of conjugate vaccination.

摘要

我们研究了肺炎链球菌荚膜抗体调理作用对DNA水平转移的影响。调理作用并未抑制DNA摄取。这表明荚膜基因的水平转移作为病原体的一种重要逃逸机制，仍然对结合疫苗接种的效果构成潜在威胁。

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