da Costa P, Yasuda C L, Scagliusi S M, Diaz-Bardales B M, Maciel E, Damasceno B P, Blotta M H, Tilbery C P, Santos L M
Department of Microbiology and Immunology, Institute of Biology, UNICAMP, Campinas, Brazil.
Mult Scler. 2000 Oct;6(5):293-9. doi: 10.1177/135245850000600501.
Autoimmune T cells play a key role as regulators and effectors of organ-specific autoimmune disease. In multiple sclerosis (MS), activated T cells specific for myelin components produce a plethora of inflammatory cytokines and mediators that contribute to myelin damage. The production of proinflammatory and regulatory cytokines by peripheral blood cells from patients with active and stable MS and healthy controls were examined. The results show that TNF alpha production was somewhat elevated in active MS with no significant increase in the level IFN gamma, whereas in the chronic phase the anti-inflammatory cytokines IL-10 and TGF beta increased, accompanied by a reduction in IFN gamma when stimulated by myelin basic protein. Multiple Sclerosis (2000) 6 293 - 299
自身免疫性T细胞作为器官特异性自身免疫疾病的调节因子和效应因子发挥关键作用。在多发性硬化症（MS）中，针对髓鞘成分的活化T细胞产生大量促炎细胞因子和介质，导致髓鞘损伤。对活动期和稳定期MS患者以及健康对照者外周血细胞产生促炎和调节性细胞因子的情况进行了检测。结果显示，活动期MS患者肿瘤坏死因子α（TNFα）的产生有所升高，而干扰素γ（IFNγ）水平无显著增加；而在慢性期，抗炎细胞因子白细胞介素-10（IL-10）和转化生长因子β（TGFβ）增加，同时在髓鞘碱性蛋白刺激下IFNγ减少。《多发性硬化症》（2000年）6卷 293 - 299页
