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伊朗组织相容性抗原(HLA)与多发性硬化症的关联。

Histocompatibility antigen (HLA) associations with multiple sclerosis in Iran.

作者信息

Kalanie H, Kamgooyan M, Sadeghian H, Kalanie A R

机构信息

Department of Neurology, Shohada Hospital, Tajrish, Tehran, Iran.

出版信息

Mult Scler. 2000 Oct;6(5):317-9. doi: 10.1177/135245850000600504.

Abstract

Human leukocyte antigen (HLA) types were obtained from 79 Iranian patients with multiple sclerosis and compared with 100 controls. The prevalence of HLA-A24 (30.3% versus 18.0%), HLA-DR2 (43.0% versus 28. 0%) and HLA-DR15 (36.7% versus 23.0%) were significantly increased in multiple sclerosis patients compared with controls. However age at onset, and disease status (relapsing - remitting or primary progressive) did not show an association with any particular HLA type. Multiple Sclerosis (2000) 6 317 - 319

摘要

从79名伊朗多发性硬化症患者身上获取了人类白细胞抗原(HLA)类型,并与100名对照者进行了比较。与对照组相比,多发性硬化症患者中HLA - A24(30.3%对18.0%)、HLA - DR2(43.0%对28.0%)和HLA - DR15(36.7%对23.0%)的患病率显著升高。然而,发病年龄和疾病状态(复发缓解型或原发进展型)与任何特定的HLA类型均无关联。《多发性硬化症》(2000年)6卷 317 - 319页

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