Karmouni T, Rioux-Leclercq N, Bensalah K, Alva A, Patard J J, Guillé F, Lobel B
Service d'Urologie, CHRU Pontchaillou, Rennes, France.
Prog Urol. 2000 Sep;10(4):590-4.
This rare but aggressive bladder tumour presents the morphological and immunohistochemical characteristic, common to all neuroendocrine tumours observed in other organs. This study analyzed the diagnostic criteria and therapeutic results obtained in 5 consecutive patients over a 3-year period.
5 patients (3 men and 2 women) suffering from primary small cell carcinoma of the bladder were evaluated. Histological diagnosis, treatment modalities and outcome were reviewed.
The main clinical presentation was macroscopic haematuria. All tumours were invasive at the time of diagnosis. 4 patients were treated by trans urethral resection alone, 2 of whom also received adjuvant radio-chemotherapy. One patient was treated by radical cystectomy. The 4 patients treated by conservative treatment modality had progression and a shorter survival, in contrast with patient treated by radical cystectomy.
The urologist must recognize this rare histological entity, which have a poor prognosis and requires multidisciplinary management. Treatment must consist of a combination of neoadjuvant or adjuvant chemotherapy and surgery to achieve the best results.
这种罕见但侵袭性强的膀胱肿瘤呈现出与在其他器官中观察到的所有神经内分泌肿瘤共有的形态学和免疫组化特征。本研究分析了3年期间连续5例患者的诊断标准及治疗结果。
对5例原发性膀胱小细胞癌患者（3例男性，2例女性）进行评估。回顾了组织学诊断、治疗方式及结果。
主要临床表现为肉眼血尿。所有肿瘤在诊断时均已侵犯。4例患者仅接受经尿道切除术治疗，其中2例还接受了辅助放化疗。1例患者接受了根治性膀胱切除术。与接受根治性膀胱切除术的患者相比，采用保守治疗方式的4例患者病情进展且生存期较短。
泌尿外科医生必须认识到这种罕见的组织学实体，其预后较差，需要多学科管理。治疗必须包括新辅助或辅助化疗与手术相结合以取得最佳效果。
