Elkousy H, Harrelson J, Dodd L, Martinez S, Scully S
Division of Orthopaedics, Duke University, Durham, NC 27710, USA.
Clin Orthop Relat Res. 2000 Nov(380):191-8. doi: 10.1097/00003086-200011000-00026.
Granular cell tumors are uncommon tumors that may arise from various soft tissue and visceral sites. These lesions often are multifocal but, with rare exceptions, are benign. Much of the literature on granular cell tumors is based on case reports mostly in the otolaryngology literature, and most series are limited to histopathologic studies. There are no documented series of cases in the orthopaedic literature. Granular cell tumors do occur in the extremities; thus, patients with a peripheral granular cell tumor may be referred to an orthopaedist. Ten cases of benign granular cell tumor treated at the authors' institution between 1993 and 1999 are reported. Five tumors of the thigh and one tumor of the groin were treated with wide excision, whereas three tumors of the hand and one tumor of the elbow were treated with marginal resection. Although two tumors treated with attempted wide excision had positive margins, none of the tumors have recurred after an average followup of 27 months. The presentation, radiography, histologic findings, and treatment of benign granular cell tumors that distinguish it from other soft tissue lesions are discussed.
颗粒细胞瘤是一种罕见的肿瘤，可起源于各种软组织和内脏部位。这些病变通常为多灶性，但除极少数情况外，均为良性。关于颗粒细胞瘤的许多文献都基于病例报告，大多发表在耳鼻喉科文献中，而且大多数系列研究仅限于组织病理学研究。骨科文献中尚无已记录的病例系列。颗粒细胞瘤确实会发生在四肢；因此，患有周围型颗粒细胞瘤的患者可能会被转诊给骨科医生。本文报告了1993年至1999年间在作者所在机构治疗的10例良性颗粒细胞瘤病例。5例大腿肿瘤和1例腹股沟肿瘤采用广泛切除治疗，而3例手部肿瘤和1例肘部肿瘤采用边缘切除治疗。尽管2例尝试进行广泛切除的肿瘤切缘阳性，但在平均27个月的随访后，所有肿瘤均未复发。本文讨论了良性颗粒细胞瘤的临床表现、影像学表现、组织学特征以及与其他软组织病变相鉴别的治疗方法。
