Ricci M, Passaleva A, Romagnani S, Amadori A
Boll Ist Sieroter Milan. 1975 Oct 20;54(4):337-48.
Advances in understanding of bronchial asthma are to be expected from more detailed information on the immuno-pathological mechanisms involved. Reaginic IgE antibodies are responsible for the great majority of extrinsic asthma, but in some cases immune complexes could probably be also important. A great progress has been achieved after reproducible methods for detecting cellular and serum specific IgE antibodies were introduced. Moreover, the immunological and biological changes induced by immunotherapy are better known. Standardization and purification of allergenic extracts is now under study in many laboratories, our own included. As concerns the intrinsic asthma attempts to demonstrate the importance of (auto) immune mechanisms have been performed. The results of these studies are reported.
随着对支气管哮喘免疫病理机制的更详细了解，有望取得进展。反应素性IgE抗体是大多数外源性哮喘的病因，但在某些情况下，免疫复合物可能也很重要。在引入了可重复的检测细胞和血清特异性IgE抗体的方法后，已经取得了很大进展。此外，免疫疗法引起的免疫学和生物学变化也广为人知。许多实验室，包括我们自己的实验室，目前正在研究变应原提取物的标准化和纯化。关于内源性哮喘，已经尝试证明（自身）免疫机制的重要性。报告了这些研究的结果。
