Flaishon L, Hershkoviz R, Lantner F, Lider O, Alon R, Levo Y, Flavell R A, Shachar I
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
J Exp Med. 2000 Nov 6;192(9):1381-8. doi: 10.1084/jem.192.9.1381.
The mechanism by which immature B cells are sequestered from encountering foreign antigens present in lymph nodes or sites of inflammation, before their final maturation in the spleen, has not been elucidated. We show here that immature B cells fail to home to the lymph nodes. These cells can actively exclude themselves from antigen-enriched sites by downregulating their integrin-mediated adhesion to the extracellular matrix protein, fibronectin. This inhibition is mediated by interferon gamma secretion. Perturbation of interferon gamma activity in vivo leads to the homing of immature B cells to the lymph nodes. This is the first example of autocrine regulation of immune cell migration to sites of foreign antigen presentation.
在未成熟B细胞于脾脏中最终成熟之前，其被隔离以免接触存在于淋巴结或炎症部位的外来抗原的机制尚未阐明。我们在此表明，未成熟B细胞无法归巢至淋巴结。这些细胞可通过下调其整合素介导的对细胞外基质蛋白纤连蛋白的黏附，主动将自身排除在富含抗原的部位之外。这种抑制作用由γ干扰素分泌介导。体内γ干扰素活性的扰动会导致未成熟B细胞归巢至淋巴结。这是免疫细胞迁移至外来抗原呈递部位的自分泌调节的首个实例。
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