Butcher E C, Picker L J
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, CA 94305-5324, USA.
Science. 1996 Apr 5;272(5258):60-6. doi: 10.1126/science.272.5258.60.
The integration and control of systemic immune responses depends on the regulated trafficking of lymphocytes. This lymphocyte "homing" process disperses the immunologic repertoire, directs lymphocyte subsets to the specialized microenvironments that control their differentiation and regulate their survival, and targets immune effector cells to sites of antigenic or microbial invasion. Recent advances reveal that the exquisite specificity of lymphocyte homing is determined by combinatorial "decision processes" involving multistep sequential engagement of adhesion and signaling receptors. These homing-related interactions are seamlessly integrated into the overall interaction of the lymphocyte with its environment and participate directly in the control of lymphocyte function, life-span, and population dynamics. In this article a review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulated the homeostasis of immunologic resources are proposed.
全身免疫反应的整合与调控依赖于淋巴细胞的定向运输。这种淋巴细胞“归巢”过程分散了免疫库，将淋巴细胞亚群导向控制其分化和调节其存活的特殊微环境，并将免疫效应细胞靶向抗原或微生物入侵部位。最近的进展表明，淋巴细胞归巢的精确特异性是由涉及粘附和信号受体多步顺序结合的组合“决策过程”决定的。这些与归巢相关的相互作用无缝地整合到淋巴细胞与其环境的整体相互作用中，并直接参与淋巴细胞功能、寿命和群体动态的控制。本文综述了淋巴细胞归巢的分子基础，并提出了归巢生理学调节免疫资源稳态的机制。
