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用于临床研究中测量前庭眼动反射的前庭自动旋转试验(VAT)的评估。

Evaluation of the vestibular autorotation test (VAT) for measuring vestibular oculomotor reflex in clinical research.

作者信息

Corvera J, Corvera-Behar G, Lapilover V, Ysunza A

机构信息

Instituto Mexicano de Otología y Neuro-otología, México, D.F., Mexico.

出版信息

Arch Med Res. 2000 Jul-Aug;31(4):384-7. doi: 10.1016/s0188-4409(00)00068-0.

DOI:10.1016/s0188-4409(00)00068-0
PMID:11068080
Abstract

BACKGROUND

A method is needed to measure parameters of vertigo and disequilibrium. Our objective was to ascertain whether the vestibular autorotation test (VAT) gives numerical data on the vestibular oculomotor reflex (VOR) that are useful for clinical research.

METHODS

A VAT was carried out on 17 healthy young volunteers twice, with an interval of 7 days (group A), and on a single occasion on another 17 volunteers of similar age and health (group B). The parameters studied were vertical and horizontal gains and phases and horizontal eye velocity symmetry. The resulting values were paired inter-session in the same individuals of group A, and between the first test of group A with the test in group B, chosen at random. Variances for the sets of numbers in each parameter as a whole and for each frequency of stimulation were calculated and statistical validity was determined.

RESULTS

No significant differences were found between the inter-session and inter-individual results. Variances of gain (horizontal and vertical) were small, but variances of phase and symmetry were large. An analysis of frequencies of stimulation revealed that variances increased with the elevation of frequency.

CONCLUSIONS

For clinical research and evaluation, the VAT affords sufficiently consistent figures for vertical and horizontal gain in the entire spectrum of frequencies tested (2-5.9 Hz) and for horizontal phases between 2-3.9 Hz. Vertical phases and horizontal asymmetry vary too greatly for our stated purpose.

摘要

背景

需要一种方法来测量眩晕和平衡失调的参数。我们的目的是确定前庭自旋转试验(VAT)是否能提供有关前庭眼动反射(VOR)的数值数据,这些数据对临床研究有用。

方法

对17名健康年轻志愿者进行了两次VAT测试,间隔7天(A组),并对另外17名年龄和健康状况相似的志愿者进行了一次测试(B组)。研究的参数包括垂直和水平增益、相位以及水平眼速度对称性。所得值在A组的同一受试者的不同测试之间进行配对,并且在A组的第一次测试与B组的测试之间进行随机配对。计算了每个参数整体以及每个刺激频率下数字集的方差,并确定了统计有效性。

结果

在不同测试之间和个体之间的结果中未发现显著差异。增益(水平和垂直)的方差较小,但相位和对称性的方差较大。对刺激频率的分析表明,方差随频率升高而增加。

结论

对于临床研究和评估,VAT在前庭眼动反射测试(VAT)在整个测试频率范围(2 - 5.9 Hz)内的垂直和水平增益以及2 - 3.9 Hz之间的水平相位方面提供了足够一致的数据。对于我们所述的目的,垂直相位和水平不对称性变化太大。

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