Pujol J, Bello J, Deus J, Cardoner N, Martí-Vilalta J L, Capdevila A
Magnetic Resonance Center of Pedralbes, Monestir, 3, 08034, Barcelona, Spain.
Psychiatry Res. 2000 Oct 30;99(3):151-9. doi: 10.1016/s0925-4927(00)00061-5.
This study was conducted to further establish the significance of the previously reported association between depressive symptoms and demyelinating lesions in the region of the left arcuate fasciculus in multiple sclerosis patients. The Beck Depression Inventory (BDI) was broken down into its main symptom categories on the basis of well-established factor analyses from the literature, and the correlation pattern between the resulting BDI subscores and lesion measurements was analyzed. We found that lesions of the left arcuate fasciculus region were selectively associated with BDI items expressing patients' Affective Symptoms and Somatic Complaints. Specifically, lesion measurements from this brain location accounted for 26% of symptom score variance of the BDI part that includes only these two factors. Performance Difficulties and Cognitive Distortions were not consistently associated with the lesion measurement. Performance Difficulties, however, showed a high correlation with the neurologic deficit detected in the physical examination. These results show that lesions in the left arcuate fasciculus region are associated with the core of the depressive syndrome rather than marginal symptoms and, thus, further suggest that this left suprainsular brain region involves white matter tracts relevant to mood regulation.
本研究旨在进一步确定先前报道的多发性硬化症患者抑郁症状与左侧弓状束区域脱髓鞘病变之间关联的意义。根据文献中已确立的因素分析，将贝克抑郁量表（BDI）分解为主要症状类别，并分析由此产生的BDI子分数与病变测量值之间的相关模式。我们发现，左侧弓状束区域的病变与表达患者情感症状和躯体主诉的BDI项目选择性相关。具体而言，该脑区的病变测量值占BDI中仅包含这两个因素部分症状评分方差的26%。行为困难和认知扭曲与病变测量值并无一致关联。然而，行为困难与体格检查中发现的神经功能缺损高度相关。这些结果表明，左侧弓状束区域的病变与抑郁综合征的核心相关，而非边缘症状，因此进一步表明该左侧岛叶上区涉及与情绪调节相关的白质束。
