Romero G, Mandujano M, Méndez I, Sánchez C
Maestría en Rehabilitación Neurológica, Universidad Autónoma Metropolitana-Xochimilco, Calz del Hueso 1100, Col. Villa Quietud, México D.F. CP 04960, Coyoacan, Mexico.
Clin Neurophysiol. 2000 Nov;111(11):1901-6. doi: 10.1016/s1388-2457(00)00434-x.
We sought to describe if neurological damage, in terms of brain lesions, syndrome and syndrome severity led to abnormalities in the brain-stem auditory evoked potentials (BAEPs) in order to provide a profile of children that could be used as an indicator of subsequent neurological sequelae. We analyzed the BAEPs from a group of children having prior evidence of neurological damage and determined the presence of neurological sequelae when the subjects were 3 years old.
Brain-stem auditory evoked potentials (BAEPs) were carried out in a group of 154 children with perinatal neurological damage. The children were classified with neurofunctional (clinical and EEG alterations) or organic and neurofunctional brain disease (clinical, EEG and image alteration) and were all followed from the first month of life and serially for 3 years. We used principal component analysis (PCA), clustered analysis and linear correlation to determine association between BAEPs, risk factors and future sequelae.
Latencies of BAEPs decreased significantly with age, and the time of conduction was modified by the presence of neurological damage. All statistical analyses suggested positive and significant associations between risk factors (trophism and condition at birth), and the latencies of waves I, III and V as well as with IPL III-V (interpeak latency) and I-V. PCA showed that IPL I-III was also positively associated with condition at birth, severity of the neurological syndrome and encephalopathy. In addition, we found that the presence and type of sequela reflected changes in the latencies of the waves, as well as IPLs, primarily those of IPL I-III.
Our results suggest that statistical methods are often needed to analyze neurological damage. The relation between BAEPs, risk factors and neurological sequelae allowed us to obtain a profile of children, which can be then used as an aid in the prognosis of children having a risk of developing neurological sequelae.
我们试图描述神经损伤（从脑损伤、综合征及综合征严重程度方面）是否会导致脑干听觉诱发电位（BAEP）异常，以便勾勒出可作为后续神经后遗症指标的儿童特征。我们分析了一组有神经损伤既往证据的儿童的BAEP，并在这些受试者3岁时确定神经后遗症的存在情况。
对154例有围产期神经损伤的儿童进行脑干听觉诱发电位（BAEP）检测。这些儿童被分类为神经功能性（临床和脑电图改变）或器质性及神经功能性脑疾病（临床、脑电图和影像学改变），且均从出生后第一个月开始随访，连续随访3年。我们使用主成分分析（PCA）、聚类分析和线性相关分析来确定BAEP、危险因素与未来后遗症之间的关联。
BAEP的潜伏期随年龄显著缩短，神经损伤的存在会改变传导时间。所有统计分析均表明危险因素（营养状况和出生时情况）与I、III、V波潜伏期以及III-V间期（峰间期）和I-V间期之间存在显著正相关。主成分分析显示I-III间期也与出生时情况、神经综合征严重程度和脑病呈正相关。此外，我们发现后遗症的存在和类型反映了波潜伏期以及峰间期的变化，主要是I-III间期的变化。
我们的结果表明，分析神经损伤通常需要使用统计方法。BAEP、危险因素与神经后遗症之间的关系使我们能够勾勒出儿童的特征，进而可用于辅助预测有发生神经后遗症风险的儿童的预后。
