Normaznah Y, Halim A A, Outhayphone M, Zamri M R
Institute for Medical Research, Kuala Lumpur.
Malays J Pathol. 1999 Dec;21(2):123-5.
Interleukin-12 (IL-12) has been shown to induce protection in mice against Plasmodium cyanomolgi and in rhesus monkey against Plasmodium yeolii. This study is to investigate whether recombinant IL-12 can induce protection in BALB/c mice against Plasmodium berghei. Five mice were given intraperitoneal injection of 7.5 micrograms/kg body weight recombinant mouse IL-12 two days prior to challenge with 5 x 10(4) of P. berghei, while mice in the control group were injected with 0.5 ml of normal saline prior to challenge. In both groups, the parasitaemia appeared on the fourth day after the infection. There was a slight reduction in the parasite burden in mice given IL-12 and the mice also survived longer compared to controls. Statistical significance of the difference could not be determined due to the small sample size. Nevertheless, the results of the study suggested that IL-12 may be able to protect mice against P. berghei infection.
白细胞介素-12（IL-12）已被证明可诱导小鼠对食蟹猴疟原虫产生保护性免疫，并使恒河猴对约氏疟原虫产生保护性免疫。本研究旨在调查重组IL-12是否能诱导BALB/c小鼠对伯氏疟原虫产生保护性免疫。5只小鼠在受到5×10⁴个伯氏疟原虫攻击前两天，腹腔注射7.5微克/千克体重的重组小鼠IL-12，而对照组小鼠在受到攻击前注射0.5毫升生理盐水。两组小鼠在感染后第4天均出现寄生虫血症。接受IL-12治疗的小鼠体内的寄生虫负荷略有降低，且与对照组相比存活时间更长。由于样本量较小，无法确定差异的统计学显著性。尽管如此，该研究结果表明IL-12可能能够保护小鼠免受伯氏疟原虫感染。
