Ogard C G, Vestergaard H
Medicinsk afdeling E, Amtssygehuset i Herlev.
Ugeskr Laeger. 2000 Oct 9;162(41):5511.
We report a case of a 76 year-old woman who had been taking warfarin for seven years because of relapsing deep venous thrombosis. Her daily maintenance dose was 5 mg. Monthly measurements of international normalised ratio (INR) were stable between 2-3. She developed oral candidiasis and miconazole gel was prescribed. One week later she developed bleeding gums. Eight days later she was admitted to the hospital with haematuria. INR was > 10. Warfarin and the miconazole gel were withdrawn. She was treated with phytonadione. INR normalised after four days and she continued warfarin treatment. Caution should be exercised whenever the combination of warfarin and miconazole gel are prescribed.
我们报告一例76岁女性病例，该患者因复发性深静脉血栓形成服用华法林七年。她的每日维持剂量为5毫克。国际标准化比值（INR）的月度测量值在2至3之间保持稳定。她患上了口腔念珠菌病，医生开了咪康唑凝胶。一周后，她出现牙龈出血。八天后，她因血尿入院。INR大于10。停用了华法林和咪康唑凝胶。她接受了维生素K1治疗。四天后INR恢复正常，她继续服用华法林治疗。每当开具华法林和咪康唑凝胶联合用药时都应谨慎。
