Ito Y, Miyoshi E, Takeda T, Sakon M, Noda K, Tsujimoto M, Monden M, Taniguchi N, Matsuura N
Department of Surgery, Osaka Seamen's Insurance Hospital, Japan.
Am J Clin Pathol. 2000 Nov;114(5):719-25. doi: 10.1309/RAVV-8NM1-CJB7-GJFR.
Recent studies on the transcriptional factor ets-1 and carcinoma have shown that ets-1 is linked to carcinoma progression, including tumor invasion and metastasis. We studied the clinical significance of ets-1 in human hepatocellular carcinoma (HCC) by using immunohistochemical staining methods. In 99 HCC cases, the levels of ets-1 expression were analyzed in comparison with various clinicopathologic parameters, such as TNM stage, intrahepatic metastasis, histologic differentiation, and prognosis. Expression of ets-1 was scarcely detected in normal liver but markedly enhanced in noncancerous lesions adjacent to HCC lesions. In HCC lesions, ets-1 expression was observed with high incidence, although the average labeling index (LI) was lower than in noncancerous lesions. However, unexpectedly, the average LI in HCC was lower in cases of high TNM stage, poor differentiation, portal invasion, intrahepatic metastasis, large tumor size, and high Ki-67 LI. Furthermore, cases with high ets-1 expression showed better outcomes for disease-free survival than those with low ets-1 expression by univariate and multivariate analyses. These findings strongly suggest that, unlike in other neoplasms, ets-1 has a crucial role in hepatocarcinogenesis and HCC progression, especially during their early phases.
近期关于转录因子ets-1与癌症的研究表明，ets-1与癌症进展相关，包括肿瘤侵袭和转移。我们采用免疫组织化学染色方法研究了ets-1在人类肝细胞癌（HCC）中的临床意义。在99例HCC病例中，分析了ets-1的表达水平，并与各种临床病理参数进行比较，如TNM分期、肝内转移、组织学分化和预后。在正常肝脏中几乎检测不到ets-1的表达，但在HCC病变附近的非癌性病变中其表达明显增强。在HCC病变中，ets-1表达的发生率较高，尽管平均标记指数（LI）低于非癌性病变。然而，出乎意料的是，在TNM分期高、分化差、门静脉侵犯、肝内转移、肿瘤体积大以及Ki-67 LI高的HCC病例中，ets-1的平均LI较低。此外，单因素和多因素分析显示，ets-1高表达的病例无病生存期的结局优于ets-1低表达的病例。这些发现有力地表明，与其他肿瘤不同，ets-1在肝癌发生和HCC进展中，尤其是在其早期阶段，起着关键作用。
