Simons C, Walsh S E, Maillard J Y, Russell A D
Welsh School of Pharmacy, Cardiff University, UK.
Lett Appl Microbiol. 2000 Oct;31(4):299-302. doi: 10.1046/j.1472-765x.2000.00817.x.
Ortho-phthalaldehyde (OPA) is a new aromatic dialdehyde antimicrobial agent, the mechanism of action of which has been little studied. The aims of this paper are to examine what is currently known about its mechanism of action, to compare the action with that of a widely investigated aliphatic dialdehyde, glutaraldehyde (GTA), and to put forward a hypothesis that would, in the light of current knowledge, explain how OPA inactivates micro-organisms, including GTA-resistant Mycobacterium chelonae.
邻苯二甲醛（OPA）是一种新型芳香族二醛类抗菌剂，其作用机制鲜少被研究。本文旨在探讨目前已知的其作用机制，将其作用与广泛研究的脂肪族二醛戊二醛（GTA）的作用进行比较，并根据现有知识提出一个假说，以解释OPA如何使微生物失活，包括耐GTA的龟分枝杆菌。
