Herr H, You C H
Department of Dermatology, Asan-Foundation Kangnung Hospital, University of Ulsan College of Medicine, Korea.
J Korean Med Sci. 2000 Oct;15(5):551-4. doi: 10.3346/jkms.2000.15.5.551.
Although it is debatable whether Helicobacter pylori may play a role in the pathogenesis of rosacea, some authors suggested that the treatment of H. pylori might have a beneficial effect. The aim of this investigation was to compare the prevalence of H. pylori between rosacea patients and controls, and to evaluate an effect of H. pylori eradication on rosecea by a 2-week triple therapy that was composed of amoxicillin, clarithromycin and omeprazole. H. pylori was detected by using gastroscopic biopsy with Warthin-Starry stain. Forty-two (84%) of 50 patients with rosacea and 39 (78%) of 50 controls had H. pylori, showing no significant difference in prevalence. The cure rates of H. pylori in rosacea patients and controls were 80% (16/20) and 85% (17/20), respectively. There was no significant decrease in the intensity of erythema in active treatment and placebo groups both during and after the treatment. Temporary improvement in papulopustules exclusively during the treatment (within 2 weeks) could be independent of H. pylori eradication. Overall, no significant reduction in the number of papulopustules was observed in active treatment and placebo groups after the treatment (in 2 months). Taken together, our study found no significant lessening of rosacea lesions by treating H. pylori infection, which conclusively does not concur with a view that H. pylori may be related to rosacea.
尽管幽门螺杆菌是否在酒渣鼻的发病机制中起作用仍存在争议，但一些作者认为治疗幽门螺杆菌可能会产生有益效果。本研究的目的是比较酒渣鼻患者和对照组中幽门螺杆菌的患病率，并通过由阿莫西林、克拉霉素和奥美拉唑组成的为期2周的三联疗法评估根除幽门螺杆菌对酒渣鼻的影响。通过使用经Warthin-Starry染色的胃镜活检来检测幽门螺杆菌。50名酒渣鼻患者中有42名（84%）和50名对照组中有39名（78%）检测出幽门螺杆菌，患病率无显著差异。酒渣鼻患者和对照组中幽门螺杆菌的治愈率分别为80%（16/20）和85%（17/20）。在治疗期间和治疗后，积极治疗组和安慰剂组的红斑强度均无显著降低。仅在治疗期间（2周内）丘疹脓疱有暂时改善，这可能与幽门螺杆菌的根除无关。总体而言，治疗后（2个月内）积极治疗组和安慰剂组的丘疹脓疱数量均未观察到显著减少。综上所述，我们的研究发现治疗幽门螺杆菌感染并没有使酒渣鼻病变显著减轻，这最终与幽门螺杆菌可能与酒渣鼻有关的观点不一致。
