• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

补体中间体C56与急性期人血清中酵母聚糖的结合。

Binding of the complement intermediate C56 to zymosan in acute phase human sera.

作者信息

Baker P J, Rubin L G, Lint T F, McLeod B C, Gewurz H

出版信息

Clin Exp Immunol. 1975 Apr;20(1):113-24.

PMID:1106918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538180/
Abstract

C56 is known to appear in the fluid phase when zymosan is incubated at 37 degrees C with certain acute phase 'reactor' sera. In the present study, C56 was detected bound to the zymosan particle prior to its appearance free in solution. In reactor sera C56 was formed and released with kinetics similar to that of the generation and decay of a C56-binding site formed when zymosan was incubated with normal serum. Bound and fluid phase C56 was detected only in reactor sera, and was generated only by agents known preferentially to activate the properdin pathway. Elution of C56 from zymosan in hypertonic salt solutions proved to be a convenient step in the partial purification of large amounts of this haemolytically active bimolecular complex.

摘要

已知当酵母聚糖在37℃与某些急性期“反应蛋白”血清一起孵育时，C56会出现在液相中。在本研究中，在溶液中游离的C56出现之前，就检测到C56与酵母聚糖颗粒结合。在反应蛋白血清中，C56的形成和释放动力学与酵母聚糖与正常血清孵育时形成的C56结合位点的产生和衰变相似。仅在反应蛋白血清中检测到结合的和液相的C56，并且仅由已知优先激活备解素途径的因子产生。在高渗盐溶液中从酵母聚糖上洗脱C56被证明是大量这种具有溶血活性的双分子复合物部分纯化中的一个方便步骤。

相似文献

1
Binding of the complement intermediate C56 to zymosan in acute phase human sera.补体中间体C56与急性期人血清中酵母聚糖的结合。
Clin Exp Immunol. 1975 Apr;20(1):113-24.
2
Inherited deficiency of the seventh component of complement associated with nephritis. Propensity to formation of C56 and related C7-consuming activity.与肾炎相关的遗传性补体第七成分缺乏。形成C56及相关C7消耗活性的倾向。
J Clin Invest. 1978 Jun;61(6):1602-10. doi: 10.1172/JCI109080.
3
Reactive lysis: the complement-mediated lysis of unsensitized cells. II. The characterization of activated reactor as C56 and the participation of C8 and C9.反应性溶解：补体介导的未致敏细胞溶解。II. 活化反应体表征为C56以及C8和C9的参与。
J Exp Med. 1970 Apr 1;131(4):643-57. doi: 10.1084/jem.131.4.643.
4
Anaphylatoxin formation by contact activation of plasma. 3. Fixation of two different anaphylatoxin-forming complexes on zymosan.通过血浆接触激活形成过敏毒素。3. 两种不同的过敏毒素形成复合物在酵母聚糖上的固定。
Eur J Immunol. 1972 Apr;2(2):180-6. doi: 10.1002/eji.1830020216.
5
Breakdown products of C 3 in human synovial fluids.人体滑液中C3的分解产物。
J Clin Invest. 1969 Aug;48(8):1532-42. doi: 10.1172/JCI106119.
6
The reaction of zymosan with the properdin system in normal and C4-deficienct guinea pig serum. Demonstration of C3- and C5-cleaving multi-unit enzymes, both containing factor B, and acceleration of their formation by the classical complement pathway.酵母聚糖与正常及C4缺陷豚鼠血清中备解素系统的反应。含B因子的C3和C5裂解多亚基酶的证实，以及经典补体途径对其形成的加速作用。
J Immunol. 1973 Nov;111(5):1389-400.
7
C3 and C5-cleaving properdin enzymes formed on zymosan incubated with human serum: the decay and the regeneration of the enzymes.
Int Arch Allergy Appl Immunol. 1977;53(4):303-9. doi: 10.1159/000231766.
8
Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex, of the classical pathway of complement, without involvement of C1q.甘露聚糖结合蛋白的五聚体/六聚体形式与酵母聚糖的结合激活了补体经典途径的酶原C1r2C1s2复合物，而无需C1q的参与。
J Immunol. 1990 Mar 15;144(6):2287-94.
9
Complement fixation by solid phase immune complexes. Reduced capacity in SLE sera.固相免疫复合物的补体结合。系统性红斑狼疮血清中能力降低。
J Clin Lab Immunol. 1988 Jun;26(2):73-9.
10
Kinetic studies of the formation of the properdin system enzymes on zymosan: evidence that nascent C3b controls the rate of assembly.关于酵母聚糖上备解素系统酶形成的动力学研究：新生C3b控制组装速率的证据。
J Immunol. 1974 Mar;112(3):1115-23.

引用本文的文献

1
Membrane signaling by complement C5b-9, the membrane attack complex.补体膜攻击复合物C5b-9介导的膜信号传导
Immunol Res. 1993;12(3):244-57. doi: 10.1007/BF02918256.
2
Increased ion permeability of planar lipid bilayer membranes after treatment with the C5b-9 cytolytic attack mechanism of complement.在用补体的C5b-9溶细胞攻击机制处理后，平面脂质双分子层膜的离子通透性增加。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2852-6. doi: 10.1073/pnas.73.8.2852.
3
Potentiation of C56-initiated lysis by leucocyte cationic proteins, myelin basic proteins and lysine-rich histones.白细胞阳离子蛋白、髓鞘碱性蛋白和富含赖氨酸的组蛋白对C56启动的溶解作用的增强。
Immunology. 1976 Apr;30(4):467-73.
4
Inherited deficiency of the seventh component of complement associated with nephritis. Propensity to formation of C56 and related C7-consuming activity.与肾炎相关的遗传性补体第七成分缺乏。形成C56及相关C7消耗活性的倾向。
J Clin Invest. 1978 Jun;61(6):1602-10. doi: 10.1172/JCI109080.
5
Steady-state analysis of tracer exchange across the C5b-9 complement lesion in a biological membrane.生物膜中C5b - 9补体损伤处示踪剂交换的稳态分析。
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5669-73. doi: 10.1073/pnas.75.11.5669.
6
Electron spin resonance studies on interaction of complement proteins with erythrocyte membranes.补体蛋白与红细胞膜相互作用的电子自旋共振研究。
Proc Natl Acad Sci U S A. 1978 Oct;75(10):4930-4. doi: 10.1073/pnas.75.10.4930.

本文引用的文献

1
Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.豚鼠血清中溶血补体九种成分的分离、纯化及测定方法
Immunochemistry. 1966 Mar;3(2):111-35. doi: 10.1016/0019-2791(66)90292-8.
2
The fifth component of the guinea pig complement system. 3. Dissociation and transfer of C5b, and the probable site of C5b fixation.豚鼠补体系统的第五个组分。3. C5b的解离与转移以及C5b固定的可能位点。
J Immunol. 1971 Feb;106(2):480-93.
3
Lysis of erythrocytes by complement in the absence of antibody.在无抗体情况下补体对红细胞的溶解作用。
J Exp Med. 1970 Nov;132(5):898-915. doi: 10.1084/jem.132.5.898.
4
Molecular analysis of the membrane attack mechanism of complement.补体膜攻击机制的分子分析
J Exp Med. 1972 Mar 1;135(3):549-66. doi: 10.1084/jem.135.3.549.
5
Kinetic studies of the formation of the properdin system enzymes on zymosan: evidence that nascent C3b controls the rate of assembly.关于酵母聚糖上备解素系统酶形成的动力学研究：新生C3b控制组装速率的证据。
J Immunol. 1974 Mar;112(3):1115-23.
6
The reaction of zymosan with the properdin system in normal and C4-deficienct guinea pig serum. Demonstration of C3- and C5-cleaving multi-unit enzymes, both containing factor B, and acceleration of their formation by the classical complement pathway.酵母聚糖与正常及C4缺陷豚鼠血清中备解素系统的反应。含B因子的C3和C5裂解多亚基酶的证实，以及经典补体途径对其形成的加速作用。
J Immunol. 1973 Nov;111(5):1389-400.
7
Reaction mechanisms of nascent C567 (reactive lysis). I. Reaction characteristics for production of EC567 and lysis by C8 and C9.新生C567的反应机制（反应性溶解）。I. C8和C9产生EC567及溶解的反应特性。
J Immunol. 1972 Aug;109(2):353-9.
8
Studies on the inhibition of C56-initiated lysis (reactive lysis). II. C567-INH--an inhibitor of the C567 trimolecular complex of complement.关于抑制C56起始裂解（反应性裂解）的研究。II. C567-INH——补体C567三分子复合物的一种抑制剂。
Int Arch Allergy Appl Immunol. 1974;47(4):623-32. doi: 10.1159/000231255.
9
Studies of complement complex C5b,6 eluted from--EAC-6: reaction of C5b,6 with EAC4b,3b and evidence on the role of C2a and C3b in the activation of C5.从-EAC-6洗脱的补体复合物C5b,6的研究：C5b,6与EAC4b,3b的反应以及C2a和C3b在C5激活中作用的证据
J Immunol. 1974 Sep;113(3):998-1007.
10
Reaction mechanisms of nascent C567 (reactive lysis). II. Killing of a rough form of Escherichia coli by C567, C8, and C9.新生C567的反应机制（反应性溶解）。II. C567、C8和C9对粗糙型大肠杆菌的杀伤作用。
J Infect Dis. 1974 Apr;129(4):444-50. doi: 10.1093/infdis/129.4.444.