Stevens D A, Ferrington R A, Merigan T C, Marinkovich V A
Clin Exp Immunol. 1975 Sep;21(3):520-4.
Dialysed transfer factor, prepared from the leucocytes of a donor whose warts had undergone recent spontaneous regression, was used in the treatment of a child with the Wiskott--Aldrich syndrome. The child then had a spontaneous regression at multiple warty areas. A similar relationship was seen in four otherwise healthy patients in a pilot study. A randomized double-blind study of thirty patients failed to confirm a causal relationship between the transfer factor therapy (equivalent to 2-1 X 10(8) leucocytes) and wart regressions. The need for randomized trials of transfer factor therapy for diseases with a variable natural history is emphasized.
透析转移因子由疣体近期自然消退的供体白细胞制备而成，用于治疗一名患有维斯科特－奥尔德里奇综合征的儿童。该儿童随后多个疣状部位出现自然消退。在一项初步研究的另外4名健康患者中也观察到了类似关系。一项针对30名患者的随机双盲研究未能证实转移因子疗法（相当于2 - 1×10⁸白细胞）与疣体消退之间存在因果关系。强调了对于自然病史多变的疾病进行转移因子疗法随机试验的必要性。
