Murata Y, Kimura M, Robinson R G
Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.
Am J Geriatr Psychiatry. 2000 Fall;8(4):310-7.
Studies have demonstrated that poststroke depression is associated with cognitive impairment, but have failed to show improvement in cognitive function when mood improves. A consecutive series of patients with (n=41) or without (n=135) major depression were evaluated for cognitive functioning during acute hospitalization and either 3 or 6 months later. Patients with poststroke major depression whose mood improved at follow-up had significantly greater recovery in cognitive functioning than patients whose mood did not improve. Furthermore, patients whose cognitive functioning improved at follow-up had significantly greater improvement in mood than comparable patients whose cognitive function did not improve, suggesting that poststroke major depression leads to cognitive impairment and not vice versa. The failure of previous treatment studies to show cognitive improvement in poststroke patients with depression was probably due to the inclusion of patients with minor depression (not associated with cognitive impairment) or the failure of patients with major depression to respond to treatment.
研究表明，中风后抑郁与认知障碍有关，但当情绪改善时，认知功能并未显示出改善。对一系列连续的有（n = 41）或无（n = 135）重度抑郁症的患者在急性住院期间以及3个月或6个月后进行了认知功能评估。随访时情绪改善的中风后重度抑郁症患者在认知功能恢复方面明显大于情绪未改善的患者。此外，随访时认知功能改善的患者在情绪改善方面明显大于认知功能未改善的类似患者，这表明中风后重度抑郁症导致认知障碍，而非相反。先前治疗研究未能显示中风后抑郁症患者认知改善，可能是由于纳入了轻度抑郁症患者（与认知障碍无关）或重度抑郁症患者对治疗无反应。
