三元复合因子和辅助因子对于人类1型T细胞白血病病毒tax蛋白对血清反应元件的反式激活至关重要。
Ternary complex factors and cofactors are essential for human T-cell leukemia virus type 1 tax transactivation of the serum response element.
作者信息
Shuh M, Derse D
机构信息
Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
出版信息
J Virol. 2000 Dec;74(23):11394-7. doi: 10.1128/jvi.74.23.11394-11397.2000.
Abstract
The human T-cell leukemia virus type 1 Tax protein activates the expression of cellular immediate early genes controlled by the serum response element (SRE), which contains both the serum response factor (SRF) binding element (CArG box) and the ternary complex factor (TCF) binding element (Ets box). We show that TCF binding is necessary for Tax activation of the SRE and that Tax directly interacts with TCFs in vitro. In addition, Tax interactions with CREB binding protein (CBP) and p300- and CBP-associated factor were found to be essential for Tax activation of SRF-mediated transcription.
摘要
人类1型T细胞白血病病毒Tax蛋白可激活由血清反应元件（SRE）控制的细胞即早基因的表达，该元件同时包含血清反应因子（SRF）结合元件（CArG盒）和三元复合因子（TCF）结合元件（Ets盒）。我们发现，TCF结合对于Tax激活SRE是必需的，并且Tax在体外可直接与TCF相互作用。此外，还发现Tax与CREB结合蛋白（CBP）以及p300和CBP相关因子的相互作用对于Tax激活SRF介导的转录至关重要。
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本文引用的文献
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Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.选择性消除核因子κB或CREB/ATF激活的2型人类T细胞白血病病毒tax突变体无法转化原代人类T细胞。
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PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner.PCAF与Tax相互作用，并以一种不依赖组蛋白乙酰转移酶的方式刺激Tax反式激活。
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