Louvet-Vallée S
Laboratoire de biologie cellulaire du développement, UMR 7622, CNRS-université Pierre-et-Marie-Curie, Paris, France.
Biol Cell. 2000 Aug;92(5):305-16. doi: 10.1016/s0248-4900(00)01078-9.
ERM (ezrin/radixin/moesin) proteins, concentrated in actin rich cell-surface structures, cross-link actin filaments with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility and membrane trafficking. Recent analyses reveal that they are not only involved in cytoskeleton organization but also in signaling pathway. They play an important role in the activation of members of the Rho family by recruiting their regulators. The functions of ERM proteins are regulated by their conformational charges: the intramolecular interaction between the N- and C-terminal domains of ERM proteins charges masks several binding sites, leading to a dormant protein. Different activation signals regulate ERM proteins functions by modulating these intramolecular interactions. The involvement of ERM proteins in many signaling pathways has led to study their role during development of different species.
ERM（埃兹蛋白/根蛋白/膜突蛋白）家族蛋白集中于富含肌动蛋白的细胞表面结构中，将肌动蛋白丝与质膜交联在一起。它们参与微绒毛的形成、细胞间黏附、细胞形状的维持、细胞运动及膜运输。最近的分析表明，它们不仅参与细胞骨架的组织，还涉及信号通路。它们通过招募Rho家族成员的调节因子，在Rho家族成员的激活中发挥重要作用。ERM蛋白的功能受其构象变化调控：ERM蛋白N端和C端结构域之间的分子内相互作用掩盖了多个结合位点，导致蛋白处于休眠状态。不同的激活信号通过调节这些分子内相互作用来调控ERM蛋白的功能。ERM蛋白参与多种信号通路，这促使人们去研究它们在不同物种发育过程中的作用。
