复杂性区域疼痛综合征中皮肤乳酸增加：组织缺氧的证据？
Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?
作者信息
Birklein F, Weber M, Neundörfer B
机构信息
Neurologische Klinik, Friedrich-Alexander-Universität Erlangen, Germany.
出版信息
Neurology. 2000 Oct 24;55(8):1213-5. doi: 10.1212/wnl.55.8.1213.
To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on patients with CRPS (n = 11) and healthy control subjects (n = 11). In addition, they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia.
为研究复杂性区域疼痛综合征（CRPS）中的氧代谢情况，作者对11例CRPS患者和11例健康对照者进行了真皮微透析，测量其皮肤乳酸水平。此外，他们还测量了血乳酸水平。虽然静脉血乳酸水平未改变，但CRPS患者的皮肤乳酸水平升高（2.95 mmol/L；对照者为1.74 mmol/L；p < 0.005）。这些结果提示无氧糖酵解增强，可能是慢性组织缺氧的结果。
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