Ryynänen P M, Kortesniemi M, Coderre J A, Diaz A Z, Hiismäki P, Savolainen S E
Department of Physics, University of Helsinki, Helsinki, Finland.
Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):1145-54. doi: 10.1016/s0360-3016(00)00766-5.
To create simple and reliable models for clinical practice for estimating the blood (10)B time-concentration curve after p-boronophenylalanine fructose complex (BPA-F) infusion in patients during neutron irradiation in boron neutron capture therapy (BNCT).
BPA-F (290 mg BPA/kg body weight) was infused i.v. during two hours to 10 glioblastoma multiforme patients. Blood samples were collected during and after the infusion. Compartmental models and bi-exponential function fit were constructed based on the (10)B blood time-concentration curve. The constructed models were tested with data from six additional patients who received various amounts of infused BPA-F and data from one patient who received a one-hour infusion of 170 mg BPA/kg body weight.
The resulting open two-compartment model and bi-exponential function estimate the clearance of (10)B after 290 mg BPA/kg body weight infusion from the blood with satisfactory accuracy during the first irradiation field (1 ppm, i.e., 7%). The accuracy of the two models in predicting the clearance of (10)B during the second irradiation field are for two-compartment model 1.0 ppm (8%) and 0.2 ppm (2%) for bi-exponential function. The models predict the average blood (10)B concentration with an increasing accuracy as more data points are available during the treatment.
By combining the two models, a robust and practical modeling tool is created for the estimation of the (10)B concentration in blood after BPA-F infusion.
创建简单可靠的临床实践模型，用于估计硼中子俘获疗法（BNCT）中患者在中子辐照期间静脉输注对硼苯丙氨酸果糖复合物（BPA-F）后血液中硼-10的时间-浓度曲线。
对10例多形性胶质母细胞瘤患者在两小时内静脉输注BPA-F（290mg BPA/千克体重）。在输注期间和输注后采集血样。基于硼-10血液时间-浓度曲线构建房室模型和双指数函数拟合。用另外6例接受不同剂量BPA-F输注患者的数据以及1例接受170mg BPA/千克体重1小时输注患者的数据对构建的模型进行测试。
所得的开放二房室模型和双指数函数在第一次辐照野期间（1ppm，即7%）对290mg BPA/千克体重输注后血液中硼-10的清除率估计具有令人满意的准确性。在第二次辐照野期间，二房室模型预测硼-10清除率的准确性为1.0ppm（8%），双指数函数为0.2ppm（2%）。随着治疗期间可用数据点增多，模型预测血液中硼-10平均浓度的准确性提高。
通过结合这两个模型，创建了一种强大且实用的建模工具，用于估计BPA-F输注后血液中硼-10的浓度。
