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[颞动脉炎所致头痛]

[Headache due to temporal arteritis].

作者信息

Pradalier A, Le Quellec A

机构信息

Service de médecine interne IV, hôpital Louis-Mourier, Colombes, France.

出版信息

Pathol Biol (Paris). 2000 Sep;48(7):700-6.

Abstract

Pain associated with geant cell arteritis (GCA) is typically continuous, with exacerbations that often occur at night. Contact is painful and can precipitate an exacerbation of pain lasting several hours. The superficial temporal artery is the most common target of GCA but symptoms vary according to the predominant site of arterial inflammation. As a result, GCA can present in different ways with headaches being mild or absent in some patients. In nearly 40% of patients with biopsy-documented GCA, palpation of the branches of the external carotid artery fails to demonstrate any abnormalities. This arteritis affects the aortic arch and all its branches giving rise to a broad range of neurologic symptoms, for example, ocular disease, ischemic stroke, aortic dissection, etc. About 30% of patients also have symptoms of polymyalgia rheumatica. Demonstration of an inflammatory syndrome is important and temporal artery biopsy is the last element of the diagnostic. In some locations of the GCA angiography is useful. Treatment, commonly including corticosteroids, should be initiated as early as possible. Prevention of osteoporosis should be initiated especially in elderly subjects. In some cases other treatments are useful anticoagulants, immunosuppressive therapies, dapsone.

摘要

巨细胞动脉炎(GCA)相关疼痛通常持续存在,夜间常出现疼痛加剧。触碰会引起疼痛,并可能使疼痛加剧持续数小时。颞浅动脉是GCA最常见的累及部位,但症状会因动脉炎症的主要部位而异。因此,GCA可能以不同方式表现,有些患者头痛轻微或无头痛症状。在近40%经活检证实为GCA的患者中,触诊颈外动脉分支未发现任何异常。这种动脉炎会影响主动脉弓及其所有分支,引发广泛的神经系统症状,例如眼病、缺血性中风、主动脉夹层等。约30%的患者还伴有风湿性多肌痛症状。证实存在炎症综合征很重要,颞动脉活检是诊断的最后一项检查。在GCA的某些部位,血管造影有用。治疗通常包括使用糖皮质激素,应尽早开始。尤其对于老年患者,应开始预防骨质疏松。在某些情况下,其他治疗方法也有用,如抗凝剂、免疫抑制疗法、氨苯砜。

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