Obwegeser R, Berghammer P, Muellauer-Ertl S, Kubista E, Sinzinger H
Department of Obstetrics and Gynecology, University Hospital Vienna, Austria.
Breast Cancer Res Treat. 2000 Aug;62(3):253-8. doi: 10.1023/a:1006442622417.
To assess the value of 99m-Tc-tetrofosmin (tetrofosmin) scintigraphy in patients with palpable and nonpalpable breast lesions.
Prospective, blinded trial. One hundred and fifty-nine consecutive patients with 163 breast lesions detected by clinical examination and mammography were included. Tetrofosmin scintigraphy of the breast was performed additionally to the regular diagnostic procedure. Using histologic assessment as the golden standard, sensitivity, specificity, positive and negative predictive value for tetrofosmin scintigraphy of the breast were assessed.
Overall sensitivity and specificity were 82% and 84%. The sensitivity for palpable tumors (65%) was 93% compared to 62% for non-palpable breast lesions. Malignant lesions were nearly twice as big as benign lesions (31.5 mm +/- 2.4 vs. 16.9 mm +/- 2.4). Specificity, positive and negative predictive value (84%, 89%, and 66%) did not differ significantly in palpable versus non-palpable tumors. Of malignant tumors 18% were found false negative by tetrofosmin scintigraphy.
The results suggest that tetrofosmin scintigraphy is a valuable tool for the evaluation of palpable breast cancer. In patients with non-palpable tumors, tetrofosmin scintigraphy may not add to the work-up of patients with breast cancer due to a low sensitivity rate.
评估99m-锝-替曲膦（替曲膦）闪烁扫描术在可触及和不可触及乳腺病变患者中的价值。
前瞻性、盲法试验。纳入159例经临床检查和乳腺X线摄影发现有163处乳腺病变的连续患者。在常规诊断程序之外还进行了乳腺替曲膦闪烁扫描术。以组织学评估作为金标准，评估乳腺替曲膦闪烁扫描术的敏感性、特异性、阳性和阴性预测值。
总体敏感性和特异性分别为82%和84%。可触及肿瘤的敏感性为65%，不可触及乳腺病变的敏感性为62%。恶性病变的大小几乎是良性病变的两倍（31.5毫米±2.4与16.9毫米±2.4）。可触及与不可触及肿瘤的特异性、阳性和阴性预测值（84%、89%和66%）差异无统计学意义。18%的恶性肿瘤通过替曲膦闪烁扫描术被误诊为阴性。
结果表明，替曲膦闪烁扫描术是评估可触及乳腺癌的一种有价值的工具。对于不可触及肿瘤的患者，由于敏感性较低，替曲膦闪烁扫描术可能无助于乳腺癌患者的检查。
