Tsutsu T, Hori T, Shimizu M, Orima H, Kawakami E, Fukuda S
Department of Reproduction, Nippon Veterinary and Animal Science University, Musashino-shi, Tokyo, Japan.
J Vet Med Sci. 2000 Oct;62(10):1115-9. doi: 10.1292/jvms.62.1115.
The prostatic regression effect of oral administration of a new steroidal anti-androgen, osaterone acetate, was investigated in dogs with prostatic hypertrophy. To dogs with prostatic hypertrophy, 0.1-1.0 mg/kg of osaterone acetate was orally administered for one week, and the regression rate was observed. It was shown that administration of osaterone acetate at 0.2 mg/kg or higher, sharply regressed prostatic hypertrophy during the early stage. Therefore, this agent may be clinically applicable as a therapeutic agent for benign prostatic hypertrophy.
研究了口服一种新型甾体类抗雄激素药物醋酸奥生多龙对前列腺肥大犬的前列腺消退作用。对前列腺肥大的犬口服0.1 - 1.0mg/kg醋酸奥生多龙，持续一周，并观察消退率。结果显示，给予0.2mg/kg及以上剂量的醋酸奥生多龙可在早期使前列腺肥大明显消退。因此，该药物可能在临床上用作良性前列腺肥大的治疗药物。
