Schmidt EG, Arkin CR, Fiorentino MA, Laude DA
Department of Chemistry and Biochemistry, The University of Texas at Austin, 78712, USA.
J Am Soc Mass Spectrom. 2000 Nov;11(11):1009-15. doi: 10.1016/s1044-0305(00)00173-2.
Simultaneous excitation/detection (SED), which permits observation of ion motion during an excitation event, is used to generate real-time Fourier transform ion cyclotron resonance (FTICR) excitation profiles that track the radial extent of ion motion in a trapped-ion cell. The conventional FTICR excitation profile is collected in a series of individual experiments in which peak magnitude is monitored as excitation voltage is increased. In contrast, SED permits the single-scan detection of ion cyclotron motion within the trapped-ion cell and consequently yields the data that produces a real-time excitation profile. Data analysis techniques are presented that facilitate conversion of a time domain SED profile into an excitation profile. An order of magnitude decrease in the amount of time is required to acquire an excitation profile, while the precision of the measurement is improved. To demonstrate the utility of the technique, it is applied to the study of axial and radial ion loss mechanisms for argon, benzene, and acetophenone ions under different conditions. SED excitation profiles are also used to illustrate the facility of quadrupolar excitation for minimizing radial ion loss.
同时激发/检测（SED）技术能够在激发事件期间观察离子运动，用于生成实时傅里叶变换离子回旋共振（FTICR）激发谱，以追踪捕获离子池中离子运动的径向范围。传统的FTICR激发谱是在一系列单独实验中收集的，其中随着激发电压的增加监测峰强度。相比之下，SED允许在捕获离子池中对离子回旋运动进行单次扫描检测，从而产生用于生成实时激发谱的数据。本文介绍了有助于将时域SED谱转换为激发谱的数据分析技术。获取激发谱所需的时间量减少了一个数量级，同时测量精度得到提高。为了证明该技术的实用性，将其应用于研究不同条件下氩离子、苯离子和苯乙酮离子的轴向和径向离子损失机制。SED激发谱还用于说明四极激发在最小化径向离子损失方面的便利性。
