• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Modification of the aza-robinson annulation for the synthesis of 4-methyl-benzo[c]quinolizin-3-ones, potent inhibitors of steroid 5alpha-reductase 1.

作者信息

Guarna A, Lombardi E, Machetti F, Occhiato E G, Scarpi D

机构信息

Dipartimento di Chimica Organica "U. Schiff" and Centro di Studio sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni, C.N.R., Università di Firenze, Via G. Capponi 9, I-50121 Firenze, Italy.

出版信息

J Org Chem. 2000 Nov 17;65(23):8093-5. doi: 10.1021/jo000603t.

DOI:10.1021/jo000603t
PMID:11073627
Abstract
摘要

相似文献

1
Modification of the aza-robinson annulation for the synthesis of 4-methyl-benzo[c]quinolizin-3-ones, potent inhibitors of steroid 5alpha-reductase 1.用于合成4-甲基苯并[c]喹嗪-3-酮（甾体5α-还原酶1的强效抑制剂）的氮杂-罗宾逊环化反应的修饰
J Org Chem. 2000 Nov 17;65(23):8093-5. doi: 10.1021/jo000603t.
2
Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1.
Bioorg Med Chem Lett. 2000 Feb 21;10(4):353-6. doi: 10.1016/s0960-894x(99)00698-8.
3
Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1.
Bioorg Med Chem Lett. 1998 Oct 20;8(20):2871-6. doi: 10.1016/s0960-894x(98)00505-8.
4
Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5alpha-reductases 1 and 2.8-取代苯并[c]喹嗪-3-酮作为人5α-还原酶1和2双重抑制剂的合成与活性
Bioorg Med Chem Lett. 2005 Jan 3;15(1):145-8. doi: 10.1016/j.bmcl.2004.10.017.
5
Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1.苯并[c]喹嗪-3-酮：一类新型的强效且选择性的人甾体5α-还原酶1非甾体抑制剂。
J Med Chem. 2000 Oct 5;43(20):3718-35. doi: 10.1021/jm000945r.
6
Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5 alpha-reductase 1.苯并[c]喹啉嗪-3-酮（新型人5α-还原酶1选择性抑制剂）中C环修饰的作用
Bioorg Med Chem. 2001 Jun;9(6):1385-93. doi: 10.1016/s0968-0896(01)00012-8.
7
Synthesis, biological activity, and three-dimensional quantitative structure-activity relationship model for a series of benzo[c]quinolizin-3-ones, nonsteroidal inhibitors of human steroid 5alpha-reductase 1.一系列苯并[c]喹啉嗪-3-酮（人甾体5α-还原酶1的非甾体抑制剂）的合成、生物活性及三维定量构效关系模型
J Med Chem. 2004 Jul 1;47(14):3546-60. doi: 10.1021/jm031131o.
8
Three distinct reactions of 3,4-dihydroisoquinolines with azlactones: novel synthesis of imidazoloisoquinolin-3-ones, benzo[a]quinolizin-4-ones, and benzo[d]azocin-4-ones.3,4-二氢异喹啉与恶唑酮的三种不同反应：咪唑并异喹啉-3-酮、苯并[a]喹嗪-4-酮和苯并[d]氮杂环辛-4-酮的新合成方法。
Org Lett. 2006 Dec 7;8(25):5845-8. doi: 10.1021/ol062429m.
9
Benzo[c]quinolizin-3-ones theoretical investigation: SAR analysis and application to nontested compounds.
J Chem Inf Comput Sci. 2004 Nov-Dec;44(6):1987-97. doi: 10.1021/ci049837u.
10
Synthesis of tricyclic compounds as steroid 5alpha-reductase inhibitors.作为甾体5α-还原酶抑制剂的三环化合物的合成。
Chem Pharm Bull (Tokyo). 2000 Apr;48(4):552-5. doi: 10.1248/cpb.48.552.

引用本文的文献

1
Kinetic Resolution of Heterocyclic Lactams by a Photocatalytic Cobalt-Catalyzed Dehydrogenation.光催化钴催化脱氢法对杂环内酰胺的动力学拆分
J Am Chem Soc. 2025 Jul 23;147(29):25148-25152. doi: 10.1021/jacs.5c07524. Epub 2025 Jul 10.
2
An -Robinson Annulation Strategy for the Synthesis of Fused Bicyclic Amides: Synthesis of (±)-Coniceine and Quinolizidine.用于合成稠合双环酰胺的An-Robinson环化策略：（±）-coniine和喹诺里西啶的合成。
Org Lett. 2023 Nov 3;25(43):7940-7945. doi: 10.1021/acs.orglett.3c02798. Epub 2023 Oct 25.
3
Enantioselective annulations for dihydroquinolones by in situ generation of azolium enolates.
通过原位生成唑鎓烯醇盐实现二氢喹诺酮的对映选择性环化反应。
J Am Chem Soc. 2014 Jul 30;136(30):10589-92. doi: 10.1021/ja505880r. Epub 2014 Jul 15.
4
Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.底物和碳正离子中间类似物与aristolochene 合酶结合的机制见解。
Biochemistry. 2013 Aug 13;52(32):5441-53. doi: 10.1021/bi400691v. Epub 2013 Aug 1.