Clemens B, Szigeti G, Barta Z
Neurological Department, Neurology Unit and Epilepsy Centre, Kenézy Gyula Memorial Hospital, Epilepsy Centre, Bartók Béla út 3, 4031, Debrecen, Hungary.
Epilepsy Res. 2000 Dec;42(2-3):105-15. doi: 10.1016/s0920-1211(00)00167-4.
The objective of this study was to investigate EEG frequency profiles (topographic distribution of spectral power data) in well-defined idiopathic generalised epilepsy (IGE) syndromes: juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), epilepsy with grand mal seizures on awakening (EGMA), and in the unified 'common IGE' (CIGE) group of these patients.
Absolute and relative (percent) power values were computed from waking EEG activity by Fast Fourier Transform (FFT). Each patient group was compared to an age-matched group of healthy control persons.
There was a general tendency for diffuse (absolute and relative) delta-theta-alpha power excess and relative beta power deficit in all IGE groups as compared to controls. Statistically significant (P</=0.05) bilateral absolute power differences were: fronto-parietal delta and diffuse theta (in JAE), frontal delta (in JME) and frontal alpha (in EGMA). Statistically significant (P</=0. 05) relative power differences were: frontal delta, diffuse theta, fronto-centro-parietal beta (in JAE), frontal delta and beta (in JME) and fronto-central alpha (in EGMA). The CIGE group showed power alterations of the same type but differences were statistically more significant than in the other patient groups.
Absolute power findings were interpreted as enhanced neuronal synchrony in the 0.5-12.0 Hz frequency range together with the tendency of decreasing synchrony in faster (12.5-32.0 Hz) frequencies. Corresponding shifts in relative power were interpreted as reflecting dysfunction of cortical regions. The authors hypothesise that these IGE frequency profiles reflect widespread cortical dysfunction essentially common to all the investigated IGE syndromes.
本研究的目的是调查明确的特发性全身性癫痫（IGE）综合征中的脑电图频率分布（频谱功率数据的地形图分布）：青少年失神癫痫（JAE）、青少年肌阵挛癫痫（JME）、觉醒时伴大发作的癫痫（EGMA），以及这些患者的统一“常见IGE”（CIGE）组。
通过快速傅里叶变换（FFT）从清醒脑电图活动中计算绝对功率值和相对（百分比）功率值。将每个患者组与年龄匹配的健康对照组进行比较。
与对照组相比，所有IGE组均普遍存在弥漫性（绝对和相对）δ-θ-α功率过剩以及相对β功率不足的趋势。具有统计学意义（P≤0.05）的双侧绝对功率差异为：额顶叶δ波和弥漫性θ波（在JAE中）、额叶δ波（在JME中）和额叶α波（在EGMA中）。具有统计学意义（P≤0.05）的相对功率差异为：额叶δ波、弥漫性θ波、额中央顶叶β波（在JAE中）、额叶δ波和β波（在JME中）以及额中央α波（在EGMA中）。CIGE组显示出相同类型的功率改变，但差异在统计学上比其他患者组更显著。
绝对功率结果被解释为在0.5 - 12.0 Hz频率范围内神经元同步性增强，同时在更快（12.5 - 32.0 Hz）频率下同步性有降低的趋势。相对功率的相应变化被解释为反映皮质区域功能障碍。作者推测这些IGE频率分布反映了所有研究的IGE综合征基本共有的广泛皮质功能障碍。
