Dodrill C B, Arnett J L, Deaton R, Lenz G T, Sommerville K W
Regional Epilepsy Center, Departments of Neurology and Neurological Surgery, University of Washington School of Medicine, Seattle, WA, USA.
Epilepsy Res. 2000 Dec;42(2-3):123-32. doi: 10.1016/s0920-1211(00)00169-8.
The effects of tiagabine (TGB) on abilities and on adjustment and mood are as yet incompletely understood. These effects were compared with those of phenytoin (PHT) and carbamazepine (CBZ) in an add-on study. Patients included in the analysis were adults with uncontrolled partial seizures who at study entry were on CBZ alone (n=153) or on PHT alone (n=124). Of the patients receiving CBZ, 82 were randomized to add-on TGB and 71 were randomized to add-on PHT during the double-blind period. Of the patients receiving PHT, 58 were randomized to add-on TGB and 66 were randomized to add-on CBZ. Eight tests of mental abilities and three of mood and adjustment were given prior to assignment of add-on treatment and after up to 16 weeks of add-on treatment. For the baseline CBZ group, analyses were done to search for differential changes from baseline in the test scores of the add-on TGB and add-on PHT groups, and for the baseline PHT group in the add-on TGB and add-on CBZ groups. In the baseline CBZ group, no differences in test scores were found between PHT and TGB. In the baseline PHT group for the area of abilities, patients treated with TGB had improved verbal fluency, as well as quicker responses on a test of perceptual/motor speed compared with patients treated with CBZ. For the baseline PHT group in the area of adjustment and mood, patients treated with TGB reported less positive mood and more financial concerns compared to patients treated with CBZ. Overall, add-on TGB showed few or no differences in comparison with add-on CBZ and add-on PHT.
噻加宾（TGB）对能力、适应能力及情绪的影响目前尚未完全明确。在一项附加治疗研究中，将这些影响与苯妥英（PHT）和卡马西平（CBZ）的影响进行了比较。纳入分析的患者为成人，患有未得到控制的部分性癫痫发作，研究开始时单独服用CBZ（n = 153）或单独服用PHT（n = 124）。在双盲期，接受CBZ治疗的患者中，82例被随机分配接受附加TGB治疗，71例被随机分配接受附加PHT治疗。接受PHT治疗的患者中，58例被随机分配接受附加TGB治疗，66例被随机分配接受附加CBZ治疗。在进行附加治疗前及附加治疗长达16周后，进行了八项心理能力测试以及三项情绪和适应能力测试。对于基线CBZ组，分析旨在寻找附加TGB组和附加PHT组测试分数相对于基线的差异变化，以及附加TGB组和附加CBZ组中基线PHT组的差异变化。在基线CBZ组中，PHT和TGB之间未发现测试分数有差异。在基线PHT组的能力方面，与接受CBZ治疗的患者相比，接受TGB治疗的患者言语流畅性有所提高，在感知/运动速度测试中的反应也更快。在基线PHT组的适应和情绪方面，与接受CBZ治疗的患者相比，接受TGB治疗的患者报告的积极情绪较少，且财务担忧更多。总体而言，与附加CBZ和附加PHT相比，附加TGB几乎没有差异。
