Cashin-Hemphill L, Noone M, Abbott J F, Waksmonski C A, Lees R S
Boston Heart Foundation and Harvard/MIT, Cambridge, Massachusetts 02142, USA.
Am J Cardiol. 2000 Nov 15;86(10):1160, A10. doi: 10.1016/s0002-9149(00)01183-8.
Pregnancy in patients with severe hypercholesterolemia and coronary artery disease results in multiple problems both for mother and fetus; the most potent agents for low-density lipoprotein (LDL) cholesterol reduction, the HMG-CoA reductase inhibitors (statins) cannot be used during pregnancy. We present a case in which LDL apheresis via heparin-induced extracorporeal LDL precipitation was employed safely and efficaciously during pregnancy in a woman with heterozygous familial hypercholesterolemia and stable coronary artery disease.
重度高胆固醇血症和冠状动脉疾病患者怀孕会给母亲和胎儿带来诸多问题；最有效的降低低密度脂蛋白（LDL）胆固醇的药物，即HMG-CoA还原酶抑制剂（他汀类药物）在孕期不能使用。我们报告一例，一名患有杂合子家族性高胆固醇血症和稳定型冠状动脉疾病的女性在孕期通过肝素诱导的体外LDL沉淀进行LDL单采术，该方法安全有效。
