Piletz J E, Halbreich U
Department of Psychiatry and Human Behavior, and Departments of Pharmacology and Physiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Biol Psychiatry. 2000 Nov 1;48(9):932-9. doi: 10.1016/s0006-3223(00)00849-0.
Platelet alpha(2A)-adrenoceptors (alpha(2A)AR) and imidazoline binding sites (subtype I(1)) have been proposed as peripheral markers of brain stem receptors that mediate sympathetic outflow and are reported to be elevated in major depression.
In our study, p[(125)I]-iodoclonidine was used to assess platelet alpha(2A)AR and I(1) binding sites in healthy postmenopausal women (n = 34) compared with healthy women of reproductive age (n = 26). Receptor determinations were repeated in 19 postmenopausal women following 59-60 days of estrogen replacement therapy (ERT; 0.1 mg estradiol transdermal patches).
I(1) binding sites were twofold higher in platelets of postmenopausal women compared with women of reproduction age but were down-regulated (normalized) after 59-60 days of ERT. All other binding parameters, including platelet alpha(2A)AR density, were not different between groups nor were they changed after ERT. Platelet I(1) densities after 59-60 days of ERT were positively correlated with plasma luteinizing hormone concentrations.
It is suggested that increased imidazoline binding sites might be associated with mood and behavioral changes in postmenopausal women.
血小板α（2A）-肾上腺素能受体（α（2A）AR）和咪唑啉结合位点（I（1）亚型）被认为是介导交感神经流出的脑干受体的外周标志物，据报道在重度抑郁症中升高。
在我们的研究中，使用p[（125）I]-碘可乐定评估健康绝经后妇女（n = 34）与健康育龄妇女（n = 26）的血小板α（2A）AR和I（1）结合位点。在19名绝经后妇女接受59 - 60天的雌激素替代疗法（ERT；0.1mg雌二醇透皮贴剂）后重复进行受体测定。
绝经后妇女血小板中的I（1）结合位点是育龄妇女的两倍，但在ERT 59 - 60天后下调（恢复正常）。所有其他结合参数，包括血小板α（2A）AR密度，在各组之间没有差异，ERT后也没有变化。ERT 59 - 60天后血小板I（1）密度与血浆黄体生成素浓度呈正相关。
提示咪唑啉结合位点增加可能与绝经后妇女的情绪和行为变化有关。
