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Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references.

作者信息

Pagliaro L A, Benet L Z

出版信息

J Pharmacokinet Biopharm. 1975 Oct;3(5):333-83. doi: 10.1007/BF01082306.

DOI:10.1007/BF01082306
PMID:1107513
Abstract
摘要

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Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references.对人类研究中终末半衰期、原形药物排泄百分比以及肾功能和肝功能不全时半衰期变化进行批判性汇编，并列出参考文献。
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Pharmacokinetic studies of flumecinol in man and dog.
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The pharmacological role of the kidney.肾脏的药理学作用。
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本文引用的文献

1
Absorption, distribution and excretion of streptomycin.
Arch Intern Med (Chic). 1946 Feb;77:179-95. doi: 10.1001/archinte.1946.00210370060005.
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Streptomycin in the blood; chemical determinations after single and repeated intramuscular injections.血液中的链霉素；单次及多次肌肉注射后的化学测定
J Pharmacol Exp Ther. 1948 Mar;92(3):226-35.
3
Excretion of cephaloridine and cephalothin in patients with renal impairment.肾功能损害患者中头孢菌素I和头孢噻吩的排泄情况。
N Engl J Med. 1966 Mar 24;274(12):654-6. doi: 10.1056/NEJM196603242741205.
4
The pharmacokinetics of furazlocillin in healthy humans.呋苄西林在健康人体中的药代动力学。
J Pharmacokinet Biopharm. 1983 Feb;11(1):5-30. doi: 10.1007/BF01061765.
5
Experience with brulamycin therapy in dialysed patients.
Int Urol Nephrol. 1988;20(5):539-49. doi: 10.1007/BF02550617.
6
Alcohol metabolism.酒精代谢
CMAJ. 1992 Jun 15;146(12):2141.
7
Effect of vitamin C supplement on antipyrine disposition in man.维生素C补充剂对人体中安替比林代谢的影响。
Br J Clin Pharmacol. 1977 Apr;4(2):236-9. doi: 10.1111/j.1365-2125.1977.tb00701.x.
8
Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.药理活性药物代谢物：治疗及毒性活性、人体血浆及尿液数据、肾衰竭时的蓄积情况
Clin Pharmacokinet. 1976 Nov-Dec;1(6):426-43. doi: 10.2165/00003088-197601060-00003.
9
Pharmacokinetics of the penicillins in man.青霉素在人体内的药代动力学。
Clin Pharmacokinet. 1976;1(4):297-308. doi: 10.2165/00003088-197601040-00004.
4
Determination of neostigmine and pyridostigmine in the urine of patients with myasthenia gravis.重症肌无力患者尿液中新斯的明和吡啶斯的明的测定。
Br J Pharmacol Chemother. 1962 Jun;18(3):617-24. doi: 10.1111/j.1476-5381.1962.tb01181.x.
5
Metabolism of adrenocorticosteroids in man.人类肾上腺皮质类固醇的代谢
Ann N Y Acad Sci. 1959 Oct 14;82:846-53. doi: 10.1111/j.1749-6632.1960.tb44966.x.
6
Persistence of antibiotics in blood of patients with acute renal failure. I. Tetracycline and chlortetracycline.急性肾衰竭患者血液中抗生素的持续存在。I. 四环素和金霉素
J Clin Invest. 1959 Sep;38(9):1487-97. doi: 10.1172/JCI103927.
7
Persistence of antibiotics in blood of patients with acute renal failure. II. Chloramphenicol and its metabolic products in the blood of patients with severe renal disease or hepatic cirrhosis.急性肾衰竭患者血液中抗生素的持续存在。II. 重症肾病或肝硬化患者血液中的氯霉素及其代谢产物。
J Clin Invest. 1959 Sep;38(9):1498-508. doi: 10.1172/JCI103928.
8
Persistence of antibiotics in blood of patients with acute renal failure. III. Penicillin, streptomycin, erythromycin and kanamycin.急性肾衰竭患者血液中抗生素的持续存在情况。III. 青霉素、链霉素、红霉素和卡那霉素。
J Clin Invest. 1959 Sep;38(9):1509-19. doi: 10.1172/JCI103929.
9
Distribution and excretion of four tetracycline analogues in normal young men.四种四环素类似物在正常青年男性中的分布与排泄
J Clin Invest. 1959 Nov;38(11):1950-63. doi: 10.1172/JCI103974.
10
Barbituric acid concentration in serum from patients with severe acute poisoning.重度急性中毒患者血清中的巴比妥酸浓度。
Acta Pharmacol Toxicol (Copenh). 1954;10(3):261-80. doi: 10.1111/j.1600-0773.1954.tb01343.x.