Expression of invasiveness of Campylobacter jejuni ssp. jejuni after serial intraperitoneal passages in mice.

We investigated the possibility of inducing the expression of invasiveness in 10 non-invading, laboratory-adapted Campylobacter jejuni ssp. jejuni strains, after serial intraperitoneal (i.p.) passage in mice. All the strains expressed invasive capacity after the first passage, with an increase in invasion rates and the number of internalized bacteria after each passage. These results suggest that i.p. passage enhances the expression of invasiveness in C. jejuni ssp. jejuni strains.