Goto K, Ito K, Takeshima N, Shingu C, Yoshitake S, Noguchi T
Department of Anesthesiology, Oita Medical University.
Masui. 2000 Oct;49(10):1088-91.
This study was designed to investigate the effect of olprinone hydrochloride on cerebral blood flow in ten patients after cardiac surgery by transcranial Doppler sonography (TCD). We assessed cerebral blood flow in the middle cerebral artery by transtemporal approach and in the carotid siphon by transorbital approach. We measured the mean blood flow velocity in the left middle cerebral artery (Vmca) and the left carotid siphon (Vlca) and calculated the pulsatility index in the left middle cerebral artery (PImca) and the left carotid siphon (PIlca) using 2 MHz transcranial Doppler ultrasound system (DWL Multidop-P). After baseline measurement, the olprinone hydrochloride loading dosage was increased from 0.15 to 0.3 microgram.kg-1.min-1 every 60 minutes. The mean blood flow velocity was measured at each point. Vmca and Vlca significantly increased, and PImca and PIlca significantly decreased at the infusion rate of 0.3 microgram.kg-1.min-1. There were significant linear correlations between CI and Vmca, CI and Vlca, SVRI and Vmca, as well as SVRI and Vlca. Dose-response relationships were observed in CI, SVRI, Vmca, and Vlca. In conclusion, we demonstrated that olprinone hydrochloride led to an increase of cerebral blood flow in the patients after cardiac surgery.
本研究旨在通过经颅多普勒超声（TCD）研究盐酸奥普力农对10例心脏手术后患者脑血流量的影响。我们通过颞部途径评估大脑中动脉的脑血流量，通过眶部途径评估颈动脉虹吸部的脑血流量。我们使用2兆赫兹经颅多普勒超声系统（DWL Multidop-P）测量左大脑中动脉（Vmca）和左颈动脉虹吸部（Vlca）的平均血流速度，并计算左大脑中动脉（PImca）和左颈动脉虹吸部（PIlca）的搏动指数。在基线测量后，盐酸奥普力农负荷剂量每60分钟从0.15微克·千克-1·分钟-1增加至0.3微克·千克-1·分钟-1。在每个点测量平均血流速度。在输注速率为0.3微克·千克-1·分钟-1时，Vmca和Vlca显著增加，PImca和PIlca显著降低。CI与Vmca、CI与Vlca、SVRI与Vmca以及SVRI与Vlca之间存在显著的线性相关性。在CI、SVRI、Vmca和Vlca中观察到剂量反应关系。总之，我们证明盐酸奥普力农可导致心脏手术后患者脑血流量增加。
