促性腺激素释放激素刺激试验在中枢性性早熟（CPP）诊断中的成本效益分析。
A cost-benefit of gnRH stimulation test in diagnosis of central precocious puberty (CPP).
作者信息
Wacharasindhu S, Srivuthana S, Aroonparkmongkol S, Shotelersuk V
机构信息
Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand.
出版信息
J Med Assoc Thai. 2000 Sep;83(9):1105-11.
The GnRH stimulation test is the gold standard to diagnose central precocious puberty (CPP). Conventionally, we need at least 2 hours to finish the test which seems to be costly and time consuming. In this study, we described the pattern of LH and FSH levels during the GnRH test in 27 girls who presented with various degrees of precocious puberty. We found that the blood samples at 90 and 120 min after GnRH were not necessary. To save the cost of diagnosis, the basal LH/FSH ratio > 0.2, the 30 min LH/FSH ratio after GnRH > 0.9 and the peak LH/FSH ratio > 1.0 can be used to diagnose CPP with positive predictive values (PPV) of 87.3, 89.4 and 93.8 per cent respectively.
促性腺激素释放激素（GnRH）刺激试验是诊断中枢性性早熟（CPP）的金标准。按照传统方法，我们完成该试验至少需要2小时，这似乎既昂贵又耗时。在本研究中，我们描述了27名呈现不同程度性早熟的女孩在GnRH试验期间促黄体生成素（LH）和促卵泡生成素（FSH）水平的变化模式。我们发现GnRH注射后90分钟和120分钟采集血样并无必要。为节省诊断成本，基础LH/FSH比值>0.2、GnRH注射后30分钟LH/FSH比值>0.9以及LH/FSH峰值比值>1.0可用于诊断CPP，其阳性预测值（PPV）分别为87.3%、89.4%和93.8%。
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