Marteau P, Munck A, Moreau J, Navarro J
Service de Gastroentérologie, Hôpital Européen Georges Pompidou, Paris.
Rev Mal Respir. 2000 Aug;17(3 Pt 2):785-97.
Digestive disturbances are frequent in adults with cystic fibrosis. They can lead to malnutrition which in turn is deleterious to the prognosis. We summarise the information on epidemiology, pathogenicity, signs, diagnostic criteria and treatments of exocrine pancreatic insufficiency, gastro-oesophageal reflux and denutrition (which are all frequent) but also of constipation, rectal prolapse, distal intestinal obstruction syndrome, and liver diseases. The main recommendations are the following: 1--know how to treat pancreatic insufficiency with enzyme replacement and vitamins; 2--know how to treat aggressively any gastro-esophageal reflux; 3--diagnose and treat denutrition as early as possible; 4--know the distal intestinal obstruction syndrome to avoid abusive and dangerous surgery; 5--know that the most severe hepatic diseases can be treated by liver transplantation.
成年囊性纤维化患者常出现消化功能紊乱。这些紊乱会导致营养不良，进而对预后产生不利影响。我们总结了有关外分泌性胰腺功能不全、胃食管反流和营养不良（这些情况都很常见）以及便秘、直肠脱垂、远端肠梗阻综合征和肝脏疾病的流行病学、致病性、体征、诊断标准和治疗方面的信息。主要建议如下：1. 要知道如何用酶替代疗法和维生素治疗胰腺功能不全；2. 要知道如何积极治疗任何胃食管反流；3. 尽早诊断和治疗营养不良；4. 了解远端肠梗阻综合征以避免过度和危险的手术；5. 要知道最严重的肝脏疾病可通过肝移植治疗。
