Ratnikova L A, Metel'skaia V A, Mamedov M N, Olfer'ev A M, Perova N V
Ter Arkh. 2000;72(9):13-6.
To study the relationship between major hemostasis parameters and hypertriglyceridemia with or without insulin resistance/hyperinsulinemia in men suffering from mild or moderate arterial hypertension.
Major hemostasis parameters including fibrinogen level, coagulation factor VII activity and fibrinolytic activity were analysed in groups of men with moderate or mild AH who had normal or elevated triglycerides level regarding presence or absence of insulin resistance/hyperinsulinemia.
High factor VII activity was found in both groups with insulin resistance irrespective of their triglycerides level. Patients with insulin resistance combined with hypertriglyceridemia had low fibrinolytic activity.
In men with metabolic syndrome components insulin resistance is accompanied with activation of coagulation external pathway, whereas combination of insulin resistance with hypertriglyceridemia was associated with hypofibrinolysis.
研究患有轻度或中度动脉高血压的男性中，主要止血参数与伴有或不伴有胰岛素抵抗/高胰岛素血症的高甘油三酯血症之间的关系。
对患有中度或轻度动脉高血压且甘油三酯水平正常或升高的男性群体，根据是否存在胰岛素抵抗/高胰岛素血症，分析包括纤维蛋白原水平、凝血因子VII活性和纤溶活性在内的主要止血参数。
在两组存在胰岛素抵抗的患者中均发现凝血因子VII活性较高，而不论其甘油三酯水平如何。伴有高甘油三酯血症的胰岛素抵抗患者纤溶活性较低。
在具有代谢综合征成分的男性中，胰岛素抵抗伴随着凝血外源性途径的激活，而胰岛素抵抗与高甘油三酯血症的合并存在与纤溶功能低下有关。
